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This review describes the incidence, risk factors and natural history of trastuzumab-associated cardiac toxicity reported in updated efficacy and cardiac safety analyses of metastatic and adjuvant trastuzumab clinical trials. Vaccines targeting self-antigens: mechanisms and efficacy-determining parameters. These results suggest that GPN-loop GTPases are assembly chaperones for Pol II and other protein complexes. Characterisation of the human oral microbiome in patients with coronary artery disease using next-generation sequencing of 16SrRNA amplicons. Correlations between expression levels of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase, and efficacy of 5-fluorouracil-based chemotherapy for advanced colorectal cancer. To examine the changes in the maternal mortality ratio (MMR) and causes of maternal death in Taiwan based on nationwide linked data sets. The special position of the pudendal nerve suggested that the Brazilian Common Opossum is a better model than rats or rabbits in surgical procedures with that specific nerve.
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Diagnostic principles and treatment of various syndromes connected with congenital gonadal developmental disorders. Saliva samples from 20 splenic asthenia children and 29 healthy children were collected before and after citric acid stimulation. Is it possible to avoid intra-articular screw penetration with minimal use of fluoroscopy in the application of distal radius volar plate?. Teaching and the practice of the rehabilitation of motor skills and verbal communication in general hospitals. Nevertheless, the expression of miR-145 reduced as the tunicae media vasorum ratios increased, indicating the development of LN inhibits the expression of miR-145. Ultracytochemistry of glycogen particles in human erythroblasts.
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Herein, we report the DNA sequence of two human CD1 genes, R2 and R3, distinct from those encoding the CD1a, -b and -c antigens. Identified toxicants were included in logistic and linear regression models to estimate associations with growth, adjusting for maternal age, smoking, education, pre-pregnancy body mass index (BMI), gestational weight gain, parity, child sex, cumulative breastfeeding, birth weight, gestational age, and preterm status. Mechanical properties, thermogravimetric analysis, differential scanning calorimetry and biocompatibility (Neutral red uptake assay, Skin Sensitization and Irritation Tests) were assessed. Myelin-basic protein (MBP)-like immunoreactivity was studied during development from postnatal day 1 to day 21 as a marker for the myelination process in the rat brain. A great deal of variation in opinion and practice remains regarding the most efficient use of electroconvulsive therapy (ECT) in treating depression. The interspecies cross-reactions suggested that at least one conserved protein region exists among the large subunits of these enzymes, whereas the small subunits are less conserved.
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Redistribution of the electrical charge of the mitochondrial membrane during energy conservation. Principles and methods of these automated immunoassay, reagents, ASO standard serum, automated analyzers, precision and accuracy, the present conditions and problems of automated analysis in the clinical laboratories were discussed in comparison with usual semiquantitative measurements. A common epitope on human myelin basic protein and the human T lymphocyte CD3 molecule. Using a well-studied cohort, we assessed the efficiency of these measures side by side in predicting mortality. These data show that VEGF-C promotes late steps of the metastatic process and identify the VEGF-C/VEGF receptor-3 pathway as the target not only for prevention of metastases, but also for treatment of established metastatic disease. In the insect chemoreceptor superfamily, Nasonia has 58 gustatory receptor (Gr) genes, of which 11 are pseudogenes, leaving 47 apparently intact proteins encoded. Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis. The only clue of hepatic dysfunction was mild elevation of the SGOT and SGPT. The function of gastric submucosal A-V shunts has been investigated in dogs by the injection of a bolus of dye into the arterial side of the gastric circulation and its subsequent collection from the veins so that a dilution curve is obtained of its passage across the gastric vascular bed.
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Male sex determination hinges on the development of testes in the embryo, beginning with the differentiation of Sertoli cells under the influence of the Y-linked gene SRY. Among these studies, large variations exist in MDO protocol, cell transplantation time, route and quantity, as well as methodology of outcome assessment. Extent of pre-dispersal seed destruction by insects and seed survival were measured for variousProtea species (Proteaceae) and related to seed-set, variation in seed-set, the percentage of barren infructescences and infructescence age. The airway-centered interstitial fibrosis variant of bronchiolocentric interstitial lung disease appears to have a poor outcome. Compound D is a potent vasodilator, and caused a dose-dependent relaxation of the rat tail artery preconstricted with phenylephrine with an EC50 of 1.5 microM, 4-5-fold more potent than acetylcholine. The present paper gives the results of experimental investigations of inhomogeneity parameters in the ground layer of the atmosphere. Screening for psychological distress in follow-up care to identify head and neck cancer patients with untreated distress. In this report, we describe the very uncommon forms of ocular injury that may accompany essential monoclonal gammopathy, which include crystalline keratopathy, crystal-storing histiocytosis, hypercupremic keratopathy, and maculopathy. ABO blood group antigens in parathyroid adenoma and hyperplasia.
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Rats were made neutropenic by intraperitoneal (ip) injection of cyclophosphamide. We found no difference in the tissue-specificity of X-linked and autosomal reporter genes. In the present study, women with HIV/AIDS who were admitted to the hospital for any reason were in better clinical condition compared with men. Influence of dark-rearing on the ontogenetic development of Sarotherodon mossambicus (Cichlidae, Teleostei): I. Resistance to direct-acting antiviral agents: clinical utility and significance. Eccentric muscle damage increases intermuscular coherence during a fatiguing isometric contraction. Most work in the field emphasizes the psychiatric, psychological, or biological determinants of suicide. A dairy cow is treated at 3.5 days with one active ingredient within one year.
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Antimicrobial use has been associated with increasing antimicrobial resistance. CS accumulation can then be induced by external addition of cAMP. Addition of histamine (10(-6)-10(-5) M) induced an increase in the frequency of contractions and enhanced the basal tone particularly in human samples. To characterize the early stages of bipolar disorder (BD), defined as the clinical prodrome/subsyndromal stage and first-episode phase, and strategies for their respective treatment. Biosynthesis and secretion of laminin and laminin-associated glycoproteins by nonmalignant and malignant human keratinocytes: comparison of cell lines from primary and secondary tumors in the same patient. Scanning electron microscopy studies on the healing process following experimental pulpotomy. eLearning among Canadian anesthesia residents: a survey of podcast use and content needs. Two subunits of alpha-crystallin, alphaA-crystallin and alphaB-crystallin, as well as other lens crystallins and non-crystallin cellular proteins, such as beta-enolase, heat shock protein beta-1 (HSP27), and glucose-6-phosphate isomerase (GPI) were found to be phosphorylated in vivo at specific sites. Using the most powerful techniques currently available, appropriate comparisons were made between related species or species groups at all taxonomic levels, thus allowing use of all species in the data set.
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Nerve conduction studies (NCS) performed four days after the onset of symptoms showed normal nerve conduction velocities and F-waves, and absent bilateral H-reflexes. To evaluate the potential utility of a renal function adjusted D-dimer cut-off value for improving the exclusion of pulmonary embolism. AMPA inhibited the KA response in a dose-dependent and competitive manner. The slides were then examined under light microscope to assess the positive staining in epithelium and connective tissue. Dysfunction of Neurovascular/Metabolic Coupling in Chronic Focal Epilepsy. zeta-Globin chains were not detected in 20 other patients with beta-thalassemia trait. After Edward Jenner established human vaccination over 200 years ago, attenuated poxviruses became key players to contain the deadliest virus of its own family: Variola virus (VARV), the causative agent of smallpox.
Prevalence of hepatitis B and C viruses and human immunodeficiency virus infections in women of reproductive age. Mycoplasma columbinum Isolated From a Racing Pigeon ( Columba livia ) With Arthritis. Genetic counselling of families with sporadic cases is complicated by the potential meiotic origin of the mutation in the mother resulting in germline mosaicism. The prognosis of the course and outcome of small-focus myocardial infarct depending on the T-index values on the ECG based on data from the Novosibirsk Myocardial Infarct Registry program. The low prevalence of parasites among the appendectomy specimens did not support the notion that parasites were a major cause of appendicitis in pediatric patients.
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Renal artery fibromuscular dysplasia is a well-known cause of hypertension whose presence is confirmed by its typical arteriographic appearance. Heterozygous p.I171V mutation of the NBN gene as a risk factor for lung cancer development. Patient classification is to divide patients into several classes based on different criteria. A chimeric peptide that included sequences from gp120 and gp41 of HIV type 1 was synthesized. The effect of impounding reservoirs on river waste assimilative capacity. Out of hospital the patient received a shock from an automated external defibrillator (AED) due to ventricular fibrillation (VF). Dopamine is currently considered to contribute to the pathophysiology of migraine, and dopamine receptor antagonists are prescribed in the treatment of acute migraine. Palliation of malignant upper-third oesophageal stricture by bipolar diathermy probe. Differences in the phenotypic characteristics between individuals falling prey to predators and conspecifics avoiding predation will reflect the intensity of selection on prey. The measurement of the binding of a biotherapeutic to its cellular target, receptor occupancy (RO), is increasingly important in development of biologically-based therapeutic agents.
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Prognosis and procedure in the surgical and orthodontic treatment of maxillomandibular dysmorphism. Concentrations of potassium, sodium, and urea were practically equal in all the zones of renal tissue from both groups of rats. The sex-ratio was always biased towards males except during periods of low density, when the ratio was close to unity. Increasing the interval between PII administration and irradiation from 24 hr to 48 hr had no great effect on tumor response to IPDT in this study. Normative data on scalp responses evoked by infraorbital nerve stimulation. Finally, we look ahead: what should we prepare for and which methodology-related topics may deserve attention in the near future?. Although not statistically significant, large tumor volume seems to be a negative prognostic factor. Cell sorting among prespore cells and prestalk cells in Dictyostelium discoideum was studied by using fluorochrome-labeled cells in an in vitro assay. Aging also resulted in significantly higher MS risks in both genders except for young females. Previous research on scrotal coloration among vervet monkeys was limited to experimental work on captive Ch.