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Accupain (Tramadol)

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Accupain is used to relieve moderate to moderately severe pain. Accupain is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain.

Other names for this medication:
Acuvin, Admadol, Armadol, Arrestadol, Bestodol, Bolodol, Cosdol, Damol, Dolodol, Dolstar, Domaspas, Kamadol, Mandol, Meridol, Movon, Nobligan, Nomadol, Novadol, Ospidol, Painadol, Paintrol, Paxmax, Pentazen, Ramadol, Rimol, Rybix, Ryzolt, Sayodol, Siatram, Soztram, Supridol, Tandam, Taxidol, Tramache, Tramadex, Tramex, Tramol, Tramot, Tranat, Tranzat, Trasic, Tremtec, Typhon, Ultracon, Unidol, Victadol, Xidol, Xtram, Zotadol

Similar Products:
Paxil, Ilosone, Antabuse, Benemid, Sildigra, Adalat, Feldene, Duphaston, Tevafen, Cevirin, Ecsit, Amidez, Clominex, Cefuroxime, Budeprion, Biwom,

Also known as: Tramadol


Accupain (tramadol) is a pain medicine similar to an opioid. It acts in the central nervous system (CNS) to relieve pain.

Accupain is used to treat moderate to severe pain in adults.

The extended-release form of tramadol (Accupain ER) is for around-the-clock treatment of pain. Accupain ER is not for use on an as-needed basis for pain.


Usual Adult Dose for Pain:

Adults (17 years or older): 50 to 100 mg orally every 4 to 6 hours as needed for pain -For patients not requiring rapid onset of analgesic effect: Initial dose: 25 mg orally once a day; titrate in 25 mg increments every 3 days to reach a dose of 25 mg four times a day; thereafter increase by 50 mg as tolerated every 3 days Maximum dose: 400 mg per day.

Usual Adult Dose for Chronic Pain:

Extended-Release (ER): 18 years or older (tramadol-naive): 100 mg orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day For patients CURRENTLY receiving Immediate-Release (IR) Accupain: Initial Dose: Calculate 24-hour IR requirement and initiate with a total daily ER dose rounded down to the next lowest 100 mg increment orally once a day Conversion from OTHER Opioids: Discontinue all other around the clock opioid drugs prior to initiating therapy -Initial dose: 100 mg ER orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day.

Usual Geriatric Dose for Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Geriatric Dose for Chronic Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Pediatric Dose for Pain:

Accupain is not recommended for use in pediatric patients 17 years or older: See Adult Dose.

Detailed Accupain dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Accupain are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not drink alcohol. Dangerous side effects or death could occur.

Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

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Blood flow-dependent prostaglandin f(2alpha) regulates intestinal glucose uptake from the blood. Face to face but not in the same place: A pilot study of prolonged exposure therapy. Efficacy of zoledronic acid combined with chemotherapy in treatment of skeletal metastases of non-small cell lung cancer and the bone metabolic markers. Recommendations for resistance exercise in cardiac rehabilitation. All available English-language case reports and clinical trials were included in the evaluation. Although the mechanical group (SOR) had larger measured EOAI, the greater increase in gradients with exercise in this group suggests that the TORONTO SPV is less obstructive to flow. A questionnaire was used to determine the physical conditioning activities of RAAF F/A-18 pilots.

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Highly stretchable, integrated supercapacitors based on single-walled carbon nanotube films with continuous reticulate architecture. The authors present to the reader the results of treatment of acute suppurative diseases of soft tissues with the method of topical negative pressure. We used 46 and 20 years of mortality follow-up, respectively, for 3521 Original and 3013 Offspring Framingham Heart Study participants 30 to 49 years and classified as normal weight, overweight, or obese at baseline. Actinomycin was used to detect the regulatory mechanism involved. This classification based on the level of cortication of the sinus floor is clinically useful as a method of determining if the dental implant can be placed simultaneously or not with the SAP, or can be placed even without a SAP. Magnetic resonance imaging and computed tomography provide good anatomic detail of suprasellar tumors in pediatric patients but are not able to predict histology in many cases. Expansins are suggested to mediate plant cell growth by interfering with either structural proteins or the polysaccharide network in the cell wall. Effect of diethylaminoethyl caffeine on conditioned-reflex activity in dogs. A model is derived that describes CSE at the fundamental resonant frequency and its harmonics in a planar wiggler FEL.

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PAF-AH activity has been found in urine of patients with primary GN, however the source and type of urinary PAF-AH remain unknown. Physicochemical parameters of roots of three Plumbago species, Plumbago capensis, P. This reversible transition drives the aggregation and dis-aggregation of the modified beads in heated zones within poly(ethylene terephthalate)(PET) microchannels. Moreover, physical therapy for prophylaxis of pneumonia and thrombosis is better tolerated. A novel precursor for synthesis of pure boron nitride nanotubes. Roughness-dependent friction force of the tarsal claw system in the beetle Pachnoda marginata (Coleoptera, Scarabaeidae). Effects of alterations of total muscular blood flow on local tissue clearance of radio-iodide in the cat. A simple method of enzyme immobilization was investigated which is useful for fabrication of enzyme sensors based on polymeric ion-selective membranes.

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The interactive role of income (material position) and income rank (psychosocial position) in psychological distress: a 9-year longitudinal study of 30,000 UK parents. Published studies during the past year about three topics important to the pediatric clinician-- immunizations, neonatal jaundice, and animal-induced injuries-are concisely reviewed. Neural crest cells have been studied intensively over the past 30 years, and it is increasingly apparent that their fate is, at least in part, directed extrinsically by the environment to which they are exposed in vivo. With this new method, it should be possible to measure simultaneously the activation of multiple different kinases in a single cell, enabling the quantitative dissection of signal transduction pathways. We found no clear evidence that Cisapride reduces symptoms of GOR. Triggered release due to environmental pH is evaluated as a method for release targeting. The high prevalence of asthma in pediatric patients underscores the need for effective and safe treatment in this population. Auriculo-condylar syndrome: further evidence for a new disorder. From five cell lines that exhibited low invasive ability, we selected two that had very little CCND2 expression (SCC9 and SCC15), to evaluate whether CCND2 gene transfer would increase the invasive behavior. cayetanensis infection, the duration of which ranged from 6 to 60 days.

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Finally, we tried to reverse the anti-inflammatory effect of maprotiline by propranolol (10 mg kg(-1)), prazosin (4 mg kg(-1)), yohimbine (10 mg kg(-1)), naloxone (4 mg kg(-1)) and mifepristone (5 mg kg(-1)). Furthermore, rapid-Mf-clearing CBA/Ca mice have a dramatic blood neutrophilia at 24 h p.i., whereas slow-clearing C57Bl/6 mice show no such neutrophilia. Agonist-induced CD63 mobilization and cell surface up-regulation was associated with beta-hexosaminidase, eosinophil peroxidase, and RANTES release. A primary genome-wide screen identified 334 hits that caused accumulation of CCV cargo on the cell surface. With most immunological reactions, tissue fibrosis, collagen overproduction caused by immune cytokines, is inevitably associated. In children, ACD to nickel classically occurs on the earlobes, neck, wrists, and infraumbilical area. We found that gross inferences regarding network topology, such as whether the brain is small over the counter protonix dose -world or scale-free, were robust to the template used, but that both absolute values of, and individual differences in, specific parameters such as path length, clustering, small-worldness, and degree distribution descriptors varied considerably across the resolutions studied.

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Participation in exercise-based cardiac rehabilitation is therefore strongly recommended for patients with myocardial infarction, especially for those with increased fear of movement. Neurological examination during the interictal period revealed no abnormality. Effects of Educational Interventions for Chronic Airway Disease on Primary Care. Cardiac transplant in xeloda a oral chemo drug a family pedigree of hypertrophic cardiomyopathy secondary to a mutation in the AMP gene. The experimental system indicates that the proposal is feasible and has an application prospect.

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The best one should be placed on both sides of the distal humerus, because of the sagittal cyclic forces it undergoes, but this location is anatomically impossible. Several missense mutations of the ACTH receptor (MC2-R) gene have been associated with the autosomal recessive syndrome of familial glucocorticoid deficiency. The EP were elicited by 1000 Hz fixed and enlarged tones with Doppler effect randomly presented. We evaluated the efficacy of genetic vaccination with plasmid vectors encoding PA, in protecting mice from a lethal challenge with B. The neu gene is expressed in adenohypophysial cells and their tumours. Gray matter correlates of dispositional optimism: a voxel-based morphometry study. The need for treatment of hemodynamic instability following carotid endarterectomy is associated with increased perioperative and 1-year morbidity and mortality. Replacement of Ser(168,170) with Ala promotes nuclear localization of NFATc4 and increases NFAT-mediated transcription activity. The objective was to characterize the electrocardiographic and electrophysiological features of focal atrial tachycardia (FAT) originating from the left septum (LS).

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Response of intracranial pressure to nursing interventions is inconsistent. Role of PKR and Type I IFNs in viral control during primary and secondary infection. Moreover, using the Wada test it is possible to make long term forecasts about the cognitive outcome and about the control of seizures. These results demonstrate the different responses of one insect species to two widely distributed plant flavonoids. The increasing occurrence of forest ecosystem degradation is a serious problem in tropical and subtropical regions. Low socioeconomic status (low education and income level) has been found to be associated with increased stroke mortality. Conservation tillage (CT) has been recognized as an advanced agricultural technology that may reduce drought and improve the physical condition of soils worldwide. The conversion of cholesterol to coprostanol and the concentration of urobilinogen and trypsin were significantly reduced in comparison with healthy persons.

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Two cases of pasteurellosis accompanied by exudate with semen-like odor from the wound. After reviewing the available literature we provide the reader with an idea of when and how to use frozen sections in common situations involving the gastrointestinal tract and liver as well as address the benefits and limitations in each setting. These results provide a basis for further research on respiratory motion in anesthetized dogs. We also outline our strategies to clone the mutant gene via its putative associated trinucleotide repeat sequence. Our findings suggest that miR-152 is frequently down-regulated and regulates DNMT1 in HBV-related HCC. The introduction of purine analogs and agents such as Campath-1H into the therapeutic armamentarium for chronic lymphocytic leukemia has altered the spectrum of infections. We show that the polyadenylation stimulating factor 30 (CPSF30) binding function of the NS1 protein from A/Texas/36/91 influenza virus, which is absent in the A/Puerto Rico/08/34 strain, is essential for counteracting these innate immune events in DCs. Here, we show that the protein phosphatase PP2A(Cdc55) dephosphorylates APC/C, thereby counteracting the activity of the mitotic kinase Cdc28. We used functional genomic approaches (chromatin immunoprecipitation (ChIP) and whole-genome sequencing) to identify cAMP response element-binding protein (CREB) targets following chronic nicotine administration and withdrawal (WD) in rodents. R408W (on haplotype 1) in contrast, the most common Irish PKU mutation, may have been prevalent in the amethopterin Neolithic farmers who settled in Ireland after 4500 BC.

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