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Actapin (Amlodipine)
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Actapin

Actapin is used to treat high blood pressure (hypertension) and to prevent angina (chest pain). It may help to increase your ability to exercise and decrease how often you get chest pain. It works by relaxing your blood vessels so blood can flow more easily, and in this way lowers your blood pressure. Actapin belongs to a group of medicines called calcium channel blockers.

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Also known as: Amlodipine

Description

Actapin (amlodipine) is a calcium channel blocker that dilates (widens) blood vessels and improves blood flow.

Actapin is used to treat chest pain (angina) and other conditions caused by coronary artery disease.

Actapin is also used to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack.

Amlodipine is for use in adults and children who are at least 6 years old.

Dosage

Take Actapin exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.

You may take Actapin with or without food. Take the medicine at the same time each day.

Your blood pressure will need to be checked often.

Your chest pain may become worse when you first start taking Actapin or when your dose is increased. Call your doctor if your chest pain is severe or ongoing.

If you are being treated for high blood pressure, keep using Actapin even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.

Your hypertension or heart condition may be treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or stop taking any of your medications without your doctor's advice. This is especially important if you also take nitroglycerin.

Actapin is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely.

Store at room temperature away from moisture, heat, and light.

Detailed Actapin dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include rapid heartbeats, redness or warmth in your arms or legs, or fainting.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Actapin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

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kesiya extract with melphalan reduced toxicity while retaining the therapeutic efficacy of melphalan. In addition, accumulation of L-DOX is unaffected by P-gp-mediated drug efflux as documented by in vitro experiments, in sharp contrast to the kinetic of free DOX, based on HIV PI blockade experiments. The receptor tyrosine kinases ErbB3 and ErbB4, which bind to various variants of neuregulin (NRG), play fundamental roles in neural development and in organs, which form through epithelial-mesenchymal interactions. Two novel mutations of the retinitis pigmentosa GTPase regulator gene in two Chinese families with X-linked retinitis pigmentosa. The subclinical course of the disease, with delayed and milder pathological lesions followed by quick follicular regeneration in the bursa of Fabricius in BD-3tc-inoculated birds, suggested that these amino acid substitutions made BD-3tc partially attenuated. First demonstration of some substances capable of stimulating the production of chromoproteins of myocardial tissue. Recent interest in the natural history of the virus has been stimulated by increasing recognition of LCMV infections during pregnancy, and in clusters of LCMV-associated fatal illness among tissue transplant recipients. From the source population of 441,000 inhabitants of a geographically defined area in South Finland, we systematically recruited, during a 2.5-year period, all new cases of asthma in 21- to 63-year-old adults and randomly selected control subjects. This syndrome highlights the critical role of NEUROD1 in both the development of the endocrine pancreas and the central nervous system in humans.

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The flow cytometric analysis of activated platelets of severed finger by severe injury before and after replantation. Results from recently completed and ongoing clinical trials have expanded the body of evidence for the safety and efficacy of antileukotrienes in the treatment of allergic rhinitis. CT perfusion is an emerging imaging tool that provides both qualitative and quantitative information regarding tumor angiogenesis. It regulates a wide range of biological responses such as cell growth, death, differentiation, and migration. tchadensis lived close to a lake, but not far from a sandy desert, perhaps the oldest record of desert conditions in the Neogene of northern central Africa. The evaluation of children with prolonged cough accompanied by American College of Chest Physicians guidelines. Letter to the editor: acute myeloid leukemia in a patient surviving retinoblastoma. Stronger goal pursuit and goal adjustment tendencies on admission predicted lower disability and higher QOL 6 months postdischarge. Direct polymerase chain reaction (PCR) sequencing was used to screen HBV reverse-transcriptase (RT) domain and clonal sequencing were performed for all resistance-positive samples. To our knowledge, this is the first case of a sharp foreign body gallbladder perforation in a child.

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The reality is, however, that the culture prevalent in the NHS, and even in some areas of nursing, must clearly change before such progression can be achieved. IL-15 was synergistic with TNF-alpha, whereas combinations of IL-15 and the other cytokines were merely additive. Evidence that pericytes regulate aquaporin-4 polarization in mouse cortical astrocytes. To explore the relationship between aldehye dehydrogenase-1 (ALDH-1) and biological characteristics of the stable ALDH-1 knock-down Hela cell lines. Analyses were conducted on data collected prospectively on 81 patients with supratentorial ICH. Treatment concepts in osseous manifestations of Langerhans cell histiocytosis. The carefully evaluating and prospectively following the psychopathology symptom of children with epilepsy are critical for early identification, prevention and treatment. Three hammerhead ribozymes bearing different cleavage sites in the core region of hepatitis C virus RNA (genotype 1b) were designed in this study. Influence of a Gamma Amino Acid on the Structures and Reactivity of Peptide a(3) Ions. Statistically significant weight loss was associated with dysgeusia.

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We present data concerning a revised version of the Emotional Perception Test (EPT-R), which indicates that older participants are significantly worse in prosodic perception than IQ-matched younger participants. Histamine, through its H1-receptor-mediated activities, appears to be primarily a proinflammatory agent, yet it does have some homeostatic functions in gastric acid production (H2-receptors) and the central nervous system (predominantly H3-receptors) (97, 98). Only regional but not sex differences were observed in the affinity of muscimol and bicuculline for GABAA receptors. A purposive sample of seven parents participating in the On Track study was recruited. Because cardiac troponin T and cardiac troponin I provide useful clinical information unavailable through other diagnostic techniques, they appear as promising biochemical markers in patients with CHF. The initial nasopharyngeal disease for which radiotherapy was indicated was nasopharyngeal carcinoma (six patients) and nasopharyngeal lymphoma (one patient). The enhanced activity of the combination of proguanil, atovaquone and dapsone is probably due to the combined activity of two synergistic combinations: proguanil-atovaquone and cycloguanil (metabolite of proguanil)-dapsone. Primary focal hyperhidrosis is a disorder of excessive sweating that occurs in the axillae, palms, soles, and craniofacial region in amounts greater than needed for thermal regulation. ATL is a distinct peripheral T-lymphocytic malignancy associated with human T-cell lymphotropic virus type I (HTLV-1).

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This spatial segregation may be the mechanism by which the direction of membrane traffic is controlled. In vitro gene transfer to chondrocytes and synovial fibroblasts by adenoviral vectors. In summary, the HPV-host cell interaction stimulates the PI3K/Akt/mTOR pathway and inhibits autophagy, and in combination these events benefit virus infection. Phylogenetic analysis of Newcastle disease virus isolates occurring in India during 1989-2013. A high enzyme concentration was observed in pancreatic juice on the first post-operative day. Understanding how the technology to diagnose colonic diseases is utilized in the population provides insight into both the access and processes of care.

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Hospitalisations with a first-listed ID diagnosis for American Indians and ANs residing in Alaska during 2001-2009 were selected from the Indian Health Service direct and contract health service inpatient data. Content analysis was applied on material from the semi-structured interview schedule. The influence on the signal by the dielectric function of the probe, the size of the scatterers, and the angle of incidence is investigated. When errors occur, however, NF frames are linked to underestimation. Gordon syndrome: The importance of measuring blood pressure in children. Ultrasonography and computed tomography showed a dilated common bile duct and main pancreatic duct. Here, we infer the geographic origin of Drosophila simulans using 2,014 bp of the period locus from 63 lines collected from 18 countries. Differences in haptoglobin and ferritin concentration by smoking status and pack-years of smoking were calculated as well as regression between pack-years and haptoglobin and ferritin concentration, and the effect of haptoglobin phenotype on these parameters. In SSEP examination group I has demonstrated a substantial latency prolongation of P14, NIB and N20 when compared to the control group, and the same result for P14, N20, P25 and CCT has been detected in group 2.

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Residue analysis of macrolides in poultry muscle by liquid chromatography-electrospray mass spectrometry. Between ten and 50 circulating epithelial antigen-positive cells detected by the Maintrac approach were selected randomly from each of 20 patients with breast cancer before and after surgery and were isolated using automated capillary aspiration and deposited individually onto slides for expression profiling. The impact of minor perioperative anesthesia-related incidents, events, and complications on postanesthesia care unit utilization. Surgical manipulation of the intestine resulted in qualitative and quantitative alterations in the aerobic bacteria. To show whether the effect of valproate was reversible, cells were cultured for 24, 48, or 72 h with valproate 100 or 250 microg/ml. To investigate the effect of two oral contraceptives containing 0.02 mg ethinylestradiol and 0.1 mg levonorgestrel (Formulation A, Leios), and the other containing 0.03 mg ethinylestradiol and 0.15 mg levonorgestrel (Formulation B, Stediril 30) on the serum and urinary concentrations of various markers reflecting the status of vascular tone and development of atherosclerosis. Analysis of the Vaginal Microbiome by Next-Generation Sequencing and Evaluation of its Performance as a Clinical Diagnostic Tool in Vaginitis. Department of Gynecology and Obstetrics, Rikshospitalet, Oslo University Hospital. The collaborative educational program was developed to give Korean home care nurses an opportunity to gain clinical experience in home care nursing in the United States so that they could learn how to deliver better-quality home care for patients and their informal caregivers.

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Various monocrystals of these free Fab-fragments and their complexes with the antigenic peptide corresponding to the 59-72 sequence of interleukin-2 were obtained. The role of endogenous heme oxygenase in the initiation of liver injury following limb ischemia/reperfusion. Intracellular degradation of secretion defect-type mutants of antithrombin is inhibited by proteasomal inhibitors. Due to the temporal relationship and the exclusion of other potential causes, a causal relationship between the use of the antidepressants and SIADH seems likely. The natural saponite adsorptive properties were found out to undergo changes during the process of thermoactivation.

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Consistent with the culture hypothesis, meta-perceptions about competence and admiration were more positive in Taiwan than in the UK, yet other meta-perceptions were more negative pointing to the existence of old age subtypes. However, despite the benefits of ACEI or ARB therapy, a substantial proportion of patients still experience renal morbidity and mortality. The role of Helicobacter pylori in generating of the chronic gastritis and in the maintaining of the gastroduodenal ulcerous disease, has been a major medical discovery of these past years in human gastroenterology. Demands on publicly funded ophthalmic services worldwide continue to increase with new treatments, waiting time targets, working time limits, and restricted budgets. The objective of this study is to present an experiment that evaluates the best configuration of the visual stimulus for each subject, thus minimizing the decline in performance of independent binary SSVEP-BCIs. This massive bleeding was controlled with autotransfusion using washing salvaging autotransfusion device (Cell Savor).

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Retinotopic mapping of the visual cortex for a patient with a horseshoe scotoma from geographic atrophy involving the macular region showed a loss of stimulation to the cortical areas representing the site of the atrophic lesion. Most clinical trials using dose-intensive chemotherapy exclude patients with brain metastases. In theory, different models of selection and mutation generate different predictions of frequency distributions. Induction of p57(Kip2) resulted in increased association of cdk6 with cyclin D3, without receptor-mediated T cell stimulation. Traditional classifications divide members of this order into families based on spore valve and polar capsule numbers. Alternative explanations for the optimism-pain association are discussed. Polystyrenes are also constituents of plastic debris found in the aquatic environment.

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Pleomorphic cells varied in shape from round to elongated and had large, multilobed, hyperchromatic nuclei but few nuclear mitoses. To further assess general and derived features of the cholinergic system in amphibians, we have investigated the distribution of choline acetyltransferase immunoreactive (ChAT-ir) cell bodies and fibers in the brain of the gymnophionan Dermophis mexicanus. Endothelial cell expression of intercellular adhesion molecule 1 in experimental posthemorrhagic vasospasm. Due to the complexity of its radiated sound, ship recognition is difficult. However, from immemorial time, cyanides were also used in suicide attempts. Subjects rated oral pungency from several concentrations of carbonated water both at normal atmospheric pressure (at which bubbles could form) and at 2.0 atmospheres pressure (at which bubbles did not form).

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Taken together, our observations show that high-resolution images reflecting tumor blood perfusion can be obtained by DCE-MRI. Cross-species color banding is a new FISH-based screening technique that enables the generation of a specific color banding pattern for each human chromosome based on the genomic homologies between man and various species of apes. Taking a cross-species, comparative perspective reveals that the effects of early exposure to steroid hormones depend upon the stage of development at birth or hatching, as measured along the altricial-precocial dimension. The prognostic factors reported in previous studies are not homogeneous and the clinical/pathogenic role of c-KIT expression is not clear. Vibratory onset and offset times were calculated in milliseconds from the total, left, and right Glottal Area Waveform (GAW). Polyelectrolyte-assisted formation of molecular nanoparticles exhibiting strongly enhanced fluorescence. On the problem of criminal admissability of artificial sterilization according to the current legal situation. Recent research has also indicated actions to improve vasa nervorum function in diabetes. Four-week-old male WBN/Kob rats were fed an MB-3 pellet diet containing herbal medicine (TJ-9, TJ-10 and TJ-45). It was shown that ionotropic glutamate receptors (AMPA and NMDA) are activated by a conditioned stimulus.

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These DNA nicks and breaks function as allosteric effectors of the enzyme activity. Three years after the introduction of the new drugs, drug sales indicated that the number of men receiving drug treatment was greater than the annual number of men receiving TURP operations and TUMT procedures combined. To identify important prognostic factors and determine the difference in postural control between full-term and pre-term infants. This study examines reliability and the focus of attention of evaluations of voice therapy sessions. Effect of donor age and cold storage time on outcome in recipients of kidneys donated after circulatory death in the UK: a cohort study.

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Criteria for successful neobladder surgery: patient selection and surgical construction. The optic discs were judged clinically and photographically as to whether there was glaucomatous optic neuropathy present, and visual fields were assessed for corresponding visual field loss. To evaluate the clinical characteristics and long-term prognosis of patients treated for erythema migrans in the region of Alsace, France. The patient was discharged on postoperative day 23 after an uneventful postoperative recovery acticin . The different modules in the network exhibited specific functions in cancers progression. A multifaceted residency-wide examination curriculum focused around an intensive 14-week course was associated with marked improvement on the in-training examination.

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