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Acycloguanosine (Acyclovir)

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Acycloguanosine is an antiviral medication that stops a protein (an enzyme called DNA polymerase) in the herpes simplex virus (HSV) and varicella-zoster virus (VZV). Without this enzyme, the virus can't make copies of itself.

Other names for this medication:
Accrivir, Aciherpin, Acloriv, Aclovir, Acvirall, Acycloguanosine, Acyclor, Acyclovir, Alovir, Axovir, Clovirax, Clyvir, Cutivir, Cycloex, Cyclopiz, Docvir, Herperax, Herpex, Herporax, Herpovir, Herzovir, Lyrovir, Nisivir, Ocurax, Okavir, Optiviral, Oveer, Rowapil, Spaclovir, Trikase, Virex, Viroderm, Viroxit, Virucid, Zoylex

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Also known as: Acyclovir


Acycloguanosine (acyclovir) is an antiviral drug. Acyclovir slows the growth and spread of the herpes virus in the body.

Acycloguanosine is used to treat infections caused by herpes viruses, such as genital herpes, cold sores, shingles, and chickenpox.

Acycloguanosine will not cure herpes, but it can lessen the symptoms of the infection.


Patient information about the treatment of herpes, chickenpox, or shingles is available with this medicine. Read it carefully before using this medicine.

Acyclovir is best used as soon as possible after the symptoms of herpes infection or shingles (for example, pain, burning, blisters) begin to appear.

If you are taking acyclovir for the treatment of chickenpox, it is best to start taking acyclovir as soon as possible after the first sign of the chickenpox rash, usually within one day.

Acyclovir capsules, tablets, and oral suspension may be taken with meals or on an empty stomach.

Acyclovir is best taken with a full glass (8 ounces) of water.

If you are using acyclovir oral suspension, use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.

To help clear up your herpes infection, chickenpox, or shingles, keep taking acyclovir for the full time of treatment, even if your symptoms begin to clear up after a few days. Do not miss any doses. However, do not use this medicine more often or for a longer time than your doctor ordered.

If you are taking acyclovir capsules, tablets, or oral suspension, you should drink plenty of water to avoid becoming dehydrated.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (capsules, oral suspension, or tablets): For treatment of genital herpes: Adults and children 12 years of age and older—200 milligrams (mg) five times a day for ten days. Children up to 12 years of age—Use and dose must be determined by the doctor. For prevention of recurrent outbreaks of genital herpes infections: Adults and children 12 years of age and older—200 to 400 mg two to five times a day for five days or up to twelve months, depending on how often your outbreaks of infection occur. Children up to 12 years of age—Use and dose must be determined by the doctor. For treatment of chickenpox: Adults and children who weigh over 88 pounds (40 kilograms)—800 mg four times a day for five days. Children 2 years of age and older and weighing 88 pounds (40 kilograms) or less—Dose is based on body weight and must be determined by the doctor. The usual dose is 20 mg per kilogram (kg) of body weight, up to 800 mg, four times a day for five days. Children up to 2 years of age—Use and dose must be determined by the doctor. For treatment of shingles: Adults and children 12 years of age and older—800 mg five times a day for seven to ten days. Children up to 12 years of age—Use and dose must be determined by the doctor. For injection dosage form: For treatment of herpes of the brain, genitals, or mucous membranes, or for the treatment of shingles: Adults and children 12 years of age and older—Dose is based on body weight and must be determined by the doctor. The usual dose is 5 to 10 mg of acyclovir per kg (2.3 to 4.5 mg per pound) of body weight, injected slowly into a vein over at least a one-hour period, and repeated every eight hours for five to ten days. Children up to 12 years of age—Dose is based on body weight and must be determined by the doctor. The usual dose is 10 mg to 20 mg of acyclovir per kg (4.5 mg to 9.1 mg per pound) of body weight, injected slowly into a vein over at least a one-hour period and repeated every eight hours for seven to ten days. For treatment of widespread herpes virus infection in newborns: Infants from birth to 3 months of age—Dose is based on body weight and must be determined by the doctor. The usual dose is 10 mg of acyclovir per kg (4.5 mg per pound) of body weight, injected slowly into a vein over at least a one-hour period and repeated every eight hours for ten days.


If you overdose Generic Acycloguanosine and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Acycloguanosine overdosage: problems with urinating, hallucinations, seizure.


Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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The most common side effects associated with Acycloguanosine are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Herpes infections are contagious and you can infect other people, even while you are being treated with Acycloguanosine. Avoid letting infected areas come into contact with other people. Avoid touching an infected area and then touching your eyes. Wash your hands frequently to prevent passing the infection to others.

Taking this medicine will not prevent you from passing genital herpes to your sexual partner. Avoid sexual intercourse while you have active lesions or the first symptoms of an outbreak. Genital herpes may still be contagious through "viral shedding" from your skin, even if you have no symptoms.

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All-epiphyseal semitendinosus PCL reconstruction in a 10-year-old child. To the best of our knowledge, these two mutations have not been observed before in Chinese women. The results demonstrate that TiO(2)/UV oxidative system can be an efficient, complementary method to the in vivo approaches to obtain important metabolites for further studies. Maternal and fetal modulators of lipid metabolism correlate with the development of preeclampsia. Accurate assessment can be challenging and appropriate use of CT imaging is essential. Diplopia appeared in 5 cases after surgery and disappeared in 3 months.

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