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Adapen (Adapalene)

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Adapen is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne, and is also used off-label to treat keratosis pilaris as well as other skin conditions. Among topical retinoids used to treat acne vulgaris, Adapen is considered to be the least effective, but best tolerated.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Coumadin, Persantine, Zetia, Levothroid, Cenforce, Rocaltrol, Leukeran, Lotar, Perilan, Tismazol, Mylax, Eumet, Zoloid, Emedal,

Also known as: Adapalene


Adapen is a third-generation topical retinoid primarily used in the treatment of acne. Adapen is a gel used for the treatment of acne (blackheads, whiteheads and pimples) of the face, chest or back. Adapen gel is a clear gel that powers deep inside your pores to control the buildup that leads to acne. It helps prevent the formation of new acne lesions, and can also help get rid of lesions already present. Adapen works under the skin surface to unclog pores and clear up pimples. Adapen is also known as Adapalene, Adapen, Adaferin. Generic name of Adapen is Adapalene.


It is very important that you use this medicine only as directed. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause irritation of the skin.

Do not apply this medicine to windburned or sunburned skin or on open wounds.

Do not use this medicine in or around the eyes, lips, or inside of the nose. Spread the medicine away from these areas when applying. If the medicine accidently gets on these areas, wash with water at once.

Apply the medicine to clean, dry areas of the skin affected by acne. Rub in gently and well. Wash your hands afterwards to remove any medicine that may remain on them.

To help clear up your acne completely, it is very important that you keep using this medicine for the full time of treatment , even if your symptoms begin to clear up after a short time. If you stop using this medicine too soon, your acne may return or get worse.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For topical dosage form (gel): For acne: Adults and teenagers—Apply a small amount as a thin film once a day, at least one hour before bedtime. Apply the medicine to dry, clean areas affected by acne. Rub in gently and well. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include skin redness, scaling, or irritation.


Store at a room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Throw away the after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Adapen are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Studies of this medicine have been done only in adult patients, and there is no specific information comparing use of adapalene in children up to 12 years of age with use in other age groups. In teenagers, adapalene is not expected to cause different side effects or problems than it does in adults.

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Phosphoramidon (1 mM) inhibited ET release at every density examined for both BPAEC and BAEC. Therapeutic effects and mechanisms of Opuntia dillenii Haw on atherosclerosis of rats. The population of Valle of Juruena makes use of a wide array of medicinal plants distributed in all use categories with predominance of those use in the treatments of gastrointestinal and respiratory ailments. Interaction of staphylococcal delta-toxin and synthetic analogues with erythrocytes and phospholipid vesicles. Although complete tumor resection (grade 0-I) is the goal, the surgical approach should be tailored to each patient depending on the risks and surgical morbidity. On the contrary, CPP reduced the probability of occurrence of sequences of SWRs more strongly in slices from adult than old rats. Trophic generalists may benefit disproportionately from high resource productivity in a habitat, and their cross-habitat spillover effects on natural food webs may be an important source of consumer pressure in mosaic landscapes. EGF stimulation significantly increased the level of the p-STAT5 protein and induces the shuttling of p-STAT5 from the cytoplasm into the nucleus. Films of XG, CNF, and CNF/XG composites are subjected to detailed (2)H and (13)C NMR relaxation studies.

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Depending on the preparation technique of homeotropic (DMOAP) and planar (Au) hemispheres we have observed two types of director field configurations: dipolar-like in the case of Au/DMOAP capped colloids and boojum-like in the case of DMOAP/Au capped colloids. The goal of prehospital care should be to cease the burning process as well as prevent future complications and secondary injuries for burn shock. Search by X-rays can assist in the detection of weapons, drugs, contraband, and hidden persons. Evaluation of a new chemiluminometric immunoassay, Magic Lite Chlamydia, for detecting Chlamydia trachomatis antigen from urogenital specimens. Unlike other types of molecules, DNA is not usually described by its atomic structure being instead usually described by its base-pair sequence, i.e., the textual sequence of its subsidiary molecules known as nucleotides ( adenine (A), cytosine (C), guanine (G), and thymine (T)). In this review, we discuss existing evidence supporting a unified model of gastric CSCs, including the regulatory mechanisms of this unified model in addition to the current status of stemness-related targeted therapy in GC patients. These seven miRNAs correlated with upregulated 29 target mRNAs involved in inflammatory plavix medication diet response, cell-cell interaction, apoptosis and intra-cellular signalling. Neutrophil cytosolic factor-1 (NCF1) is a component of NADPH oxidase.

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The nature of an accessory cell in bone marrow stimulating murine megakaryocytopoiesis. We are frequently asked if patients, in whom only postoperative pyrexia has been observed, should be considered as potentially susceptible to malignant hyperthermia (MHS). Three thousand, nine hundred and forty-one HCV antibody-positive PSHREG and FIB-4 are names not acronyms (EuroSIDA) patients with follow-up after 1 January 2000 were included, with causes of death classified using Coding causes of Death in HIV (CoDe) methodology. Loss of HLA-A,B,C allele products and lymphocyte function-associated antigen 3 in colorectal neoplasia. Future research should elucidate whether formation of iron-oxide-bound phosphorus driven by cable bacteria, as observed in this study, contributes to the seasonality in iron-phosphorus cycling in aquatic sediments worldwide. Variability in duration of outpatient diuretic therapy in bronchopulmonary dysplasia: a clinical experience. In many countries the hypomethylating agents (HMAs) are the major compounds to treat patients suffering from myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) with low bone marrow blast counts. However, novel molecular concepts in the intervention with LT biosynthesis seem promising.

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Glucocorticoids increase pyruvate dehydrogenase kinase-4 (PDK4) mRNA and protein expression, which phosphorylates pyruvate dehydrogenase, thereby preventing the formed pyruvate from undergoing mitochondrial oxidation. Diagnosis is initially by detecting partially degraded GAG or oligosaccharide in urine and confirmed by specific enzyme assays in serum, leukocytes, or skin fibroblasts. Riparian edaphic conditions were also increasingly favorable to more species within the regional pool along larger streams, with greater nitrogen availability (manifested as lower C:N) and more rapid mineralization of C and N (as indicated by ratios of stable isotopes) observed with downstream position in the network. The accepted view is that hippocampal newborn neurons integrate into the hippocampal network and thus participate in hippocampal cognitive functions crucial for remission. Modifications of myofilament protein phosphorylation and function in response to cardiac arrest induced in a swine model. No difference was found between the two methods concerning this bone resorption. In vitro, liposomal curcumin inhibits the proliferation of LL/2 cells and induces apoptosis and cell cycle arrest. The clinical results corresponded well with those of the animal experiments, and thus confirmed the value of the experimental model chosen. Comparison of complement-dependent cytotoxic and flow-cytometry crossmatch results before cadaveric kidney transplantation. On the basis of SDS-PAGE analyses and N-terminal amino acid sequences, 6 proteins were identified in the supernatants of the culture broths using DPY medium, among which oryzin (alkaline protease) and alpha-amylase were detected at a much higher extent for APC and MSLC than those for SFC while only oryzin was detected in mCD medium, in accordance with the activity measurements.

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In this two-armed randomized controlled trial, a total of 290 participants will be assigned to use Psyfit (experimental condition) or to a 6-month waiting list (control condition). The clinical application of RTGraphy is regarding the fact, that there is practically no disturbance of clotting process which is not represented in any change of clot construction. The action of gramicidin S on the ionic permeability of bilayer lipid membranes. The acute clinical manifestations of atherothrombotic disease are mediated by occlusive arterial thrombi that impair tissue perfusion and are composed of a core of aggregated platelets, generated by platelet activation, and a superimposed fibrin mesh produced by the coagulation cascade. We performed LA testing in 33 VKA-treated patients with definite antiphospholipid syndrome (APS) and compared the results with 100 controls subjects not receiving VKA and 110 APL-negative patients anticoagulated for reasons other than APS. In the individualized and interdisciplinary treatment assessment of intracranial findings, treatment costs must not be a primary decision criterion.

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