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Alfacal (Calcitriol)

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Alfacal is a hormonally-active, synthetic vitamin D analog prescribed to treat hypocalcemia, osteoporosis, and the prevention of corticosteroid-induced osteoporosis. Systemic Alfacal is FDA indicated to control hypocalcemia in patients on chronic renal dialysis, secondary hyperparathyroidism in those with chronic kidney disease not yet on dialysis, and hypocalcemia in patients with hypoparathyroidism and pseudohypoparathyroidism.

Other names for this medication:
Actical, Alfacalcirol, Alfarich, Bonetuf, Calbec, Calcitriol, Calday, Caltive, Citroj, Denscal, Kurecal, Laretol, Lctrol, Netxod, Osteobel, Ostonex, Ostriol, Rical, Rockbon, Roical, Rolsical, Solbiocal, Statbone, Tobalt, Trolec, Zaxial

Similar Products:
Famvir, Feldene, Cardizem, Decadron, Ambien, Cyphoden, Tranzat, Menilet, Rensure, Ocitiriz, Spectrem, Levof, Diflazon, Glypride, Triglycomet,

Also known as: Calcitriol


Generic Alfacal is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Alfacal are intestine and bone. Generic Alfacal receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Alfacal may also act on the kidney and the parathyroid glands. Generic Alfacal is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Alfacal has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Alfacal, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Alfacal in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Alfacal produces other independent beneficial effects. Alfacal is also known as Calcitriol. Generic Alfacal treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Alfacal is Calcitriol. Brand name of Generic Alfacal is Alfacal.


Generic Alfacal is available in capsules (0.25 mcg) and liquid form. Capsules must be swallowed whole. Do not crush or chew them. If you are prescribed the liquid form, use as directed. Follow dosing instructions closely. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. If you want to achieve most effective results do not stop taking Generic Alfacal suddenly.


If you overdose Generic Alfacal and you don't feel good you should visit your doctor or health care provider immediately.


Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Side effects

The most common side effects associated with Alfacal are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


It is especially important that you receive the right amounts of vitamins so that your baby will also get the vitamins needed to grow properly. Infants who are totally breast-fed and have little exposure to the sun may require vitamin D supplementation. However, taking large amounts of a dietary supplement while breast-feeding may be harmful to the mother and/or baby and should be avoided.

Only small amounts of alfacalcidol, calcifediol, calcitriol, or dihydrotachysterol pass into breast milk and these amounts have not been reported to cause problems in nursing babies.

It is not known whether doxercalciferol or paricalcitol passes into breast milk. Be sure you have discussed the risks and benefits of the supplement with your doctor.

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The prognosis of MEC is appreciated satisfactorily following histological criteria: histological grade, surgical margins, perineural invasion or vascular emboli. The aim of this study was to analyse the expression of MUC4 in cutaneous pathologies by immunohistochemistry for potential diagnostic, prognostic and therapeutic applications. Proteolysis in severe sepsis is related to oxidation of plasma protein. When viewed together and with recent large observational studies, they support a conclusion that a systolic pressure in the range of 125-135 mm Hg range is likely to be optimal on treatment for most hypertensive patients. Blood pressure did not vary with adult haemoglobin concentration. The traditional healers of the Tripura tribal community of Mirsharai use 64 plant species distributed into 38 families for treatment of various ailments. Contribution of the scrotum, testes, and testicular artery to scrotal/testicular thermoregulation in bulls at two ambient temperatures. Effects of intracuff dexamethasone on post-extubation reactions.

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In Sardinian families with genetic inheritance of multiple sclerosis type 1 diabetes is prevalent, both in multiple sclerosis patients and in healthy siblings. Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy. The files of non small cell lung cancer patients that were stages IIIB and IV at diagnosis were reviewed retrospectively. The surgeon, postoperative care staff, and patient must be aware of the signs and symptoms. Phylogenetic analysis of Demodex caprae based on mitochondrial 16S rDNA sequence. We concluded that Bergmann glial cells express calcium permeable ionotropic glutamate receptors, which might be important for generation of fast calcium signals. CYP71AV1 catalyzes three successive oxidation steps at the C12 position of amorpha-4,11-diene to produce artemisinic acid. The results showed that the coexpression of tau proteins and tubulin was present only in EMCs (2/2) and chordomas (4/6). We provide a brief overview of the limited smoking cessation treatment literature for patients with schizophrenia and compare abstinence-focused versus reduction-focused treatment modalities.

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These results suggest that perception with and without awareness and perception with and without attention are equivalent ways of describing the same underlying process distinction. However, brain biopsy is often omitted or delayed because of the invasiveness and possible complications of the procedure. These results suggest that central angiotensinergic circuits may serve to increase NA and DA release in the MnPO area, and support that a disorder in the ANG system may contribute, in part, to the elevated blood pressure of SHR. The distribution of wind farm borne jellyfish along Danish, German and Polish coasts indicates conflicts with further sectors, mainly energy and tourism. In this research, the firing behaviors of ELL pyramidal neuron under DC and AC electric field stimulus are investigated in a two-compartment neuron model. Molecular design of transition metal alkynyl complexes as building blocks for luminescent metal-based materials: structural and photophysical aspects. Pathological parameters, including tumor location in the transition and/or peripheral zone, tumor Gleason grade, tumor stage, total tumor volume and surgical margins were compared in stages T1c and T2 cases, and in transition versus peripheral zone stage T1c tumors in completely embedded whole mount specimens.

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Maillard reaction of D-glucose: identification of a colored product with conjugated pyrrole and furanone rings. Rac is a member of the Ras superfamily of GTPases and functions as a GDP/GTP-regulated switch. Photographs of standard light microscopy of fixed, human corneal sections are compared with confocal maicroscopic images. High-dose zoledronic acid narrows the periodontal space in rats. Differently from the Hill model, the proposed method provides dual dynamics of recruitment and calcium activation. Serum adenosine deaminase and cytidine deaminase activities in patients with systemic lupus erythematosus. This suggests that the levels of actos dosage radioactive contamination in these cooling ponds have little effect on the mutation rate of mitochondrial DNA in these waterfowl and that mitochondrial DNA may not be as sensitive an indicator as previously anticipated.

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To investigate the expression of DNAX-activating protein 12 (DAP12) and tartrate-resistant acid phosphatase (TRAP) in mouse monocyte RAW264.7 subjected to compressive stress. In light of the growing body of data implicating apoptosis in cataractogenesis, and in particular, the reported detection of apoptosis in posterior capsular opacification, the purported etiology of which, like that of anterior polar cataracts, is an aberrant transdifferentiation of lens epithelial cells into myofibroblastic cells, we hypothesized that apoptosis could also occur in anterior polar cataracts. We compared the results of the LNA flow-FISH with other methods of quantifying virus replication, including the use of an enhanced green fluorescent protein (EGFP) viral construct and quantitative reverse-transcription polymerase chain reaction. Adult intussusception is a rare phenomenon, multiple transient intussusceptions are even more uncommon. This suggests relative signal size changes as the visual system matures. Four CF patients (out of 1238) originally identified as carrying the p.I148T mutation in trans with a CF mutation had a second mutation (c.3199del6 or a novel mutation c.3395insA) on the p.I148T does flagyl cure infection allele. The objective of the study was to evaluate the effectiveness of a single home-based educational intervention for patients admitted with heart failure. Myosin7a deficiency results in reduced retinal activity which is improved by gene therapy. Some psychotherapists believe that certain experiences are so overwhelmingly traumatic that some victims become incapable of remembering their worst trauma except under special circumstances (e.g. Reconstruction of the oral cavity and the maxillomandibular region.

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Such effects on GABAergic currents are compatible with the convulsions and epileptic-like activity reported for OETX. Laser scanning microscope with a differential heterodyne optical probe. BIRC5 gene has the potential to be a marker for the detection and prognosis of cancer at an early age. Three patients were enrolled and the immunotherapy was well tolerated without significant toxicity. An interesting case of spontaneous inversion of the left atrial appendage was caused by an acute decrease in ventricular volume and the shortening of diastole during supraventricular tachycardia, creating a negative pressure invaginating the left atrial appendage. These results suggest that the chimeric receptor consisting of CEBiP and Pi-d2 functions as a receptor for chitin oligosaccharides and CEBiP-based chimeric receptors fused with other RLKs may also act as functional receptors. The stimulus on each trial was a small spot that appeared in different hues or, in Experiment 3, different forms. Metastases from renal cell carcinoma metastases can involve unusual sites. If this is shown to be the case larger and longer term trials will be needed to confirm the association is causal.

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Tissue reconstitution experiments showed that Fisp12/CTGF expression in dental epithelium required interaction with mesenchyme but was maintained by treatment of epithelium with transforming growth factor-1, a factor regulating Fisp12/CTGF expression in other systems, or with bone morphogenetic protein-2. An independently derived and validated predictive model for selecting patients with myocardial infarction who are likely to benefit from tissue plasminogen activator compared with streptokinase. (2002) dysphoria model and compared it to the fit of the PTSD model as depicted in the Diagnostic and Statistical Manual for Mental Disorders, Fourth Edition (DSM-IV), a correlated four-factor emotional numbing, and a correlated four-factor dysphoria model. A greater future utility for double inversion recovery (DIR) sequences is proposed to correlate cognitive impairment with MS impairment, given its higher diagnostic yield in locating and defining cortical lesions. The ribosomal deoxyribonucleic acid (DNA) arcoxia side effects with alcohol internal transcribed spacer region (ITS1) of two filarial nematodes, Loa loa and Mansonella perstans, was amplified and further sequenced to develop an species-specific polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) protocol for the differentiation of both species from Wuchereria bancrofti, three filarial nematodes with blood circulating microfilariae. These results provide the first demonstration of a regulatory link between nitrate and nitrite respiration in the denitrifying pathway. fastidiosa by overexpressing the MqsR toxin, and verified that the toxin positively regulated biofilm formation and negatively cell movement, resulting in reduced pathogenicity in citrus plants. We conclude that the long form OB-RL is expressed exclusively in the microvillous membrane of the syncytiotrophoblast and is capable of being phosphorylated, suggesting that it has signal transduction capacity. A mucosal model to study microbial biofilm development and anti-biofilm therapeutics.

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