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Alpostin (Alprostadil)
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Alpostin

Alpostin is a medicine that men take for ED (erectile dysfunction). It’s only available by prescription. This drug makes the blood vessels expand. That boosts blood flow throughout the body, including the penis, so it helps men with ED have an erection.

Other names for this medication:
Alpostin, Caverject, Edex, Muse, Prostin, Vitaros

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Also known as: Alprostadil

Description

Alpostin urethral suppository is used to treat men who have erectile dysfunction (also called sexual impotence). It belongs to a group of medicines called vasodilators that can increase blood flow by expanding blood vessels. This medicine causes an erection because it increases the blood flow to the penis.

Alpostin should not be used as a sexual aid by men who do not have erectile dysfunction. If the medicine is not used properly, permanent damage to the penis and loss of the ability to have erections could result.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Suppository

Dosage

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For the treatment of erectile dysfunction:
    • For injection dosage form:
      • Adults—1.25 to 60 micrograms (mcg) as a single dose once a day. Your exact dose will be determined by your doctor. Inject this medicine very slowly into your penis as shown to you by your doctor 10 to 30 minutes before intercourse. Allow 5 to 10 seconds to completely inject the dose. Do not inject more than one dose within 24 hours. Also, do not use this medicine for more than 2 days in a row or more than 3 times a week.

Overdose

If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store in the refrigerator. Do not freeze.

Alpostin for Injection while in the powder form can be stored at room temperature (between 15 and 25 °C or 59 and 77 °F) for 3 months. After it is mixed, the solution must be used immediately or within 24 hours and not refrigerated or frozen. Suppositories may be stored at room temperature.

Side effects

The most common side effects associated with Alpostin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Although appropriate studies on the relationship of age to the effects of Alpostin injection have not been performed in the geriatric population, no geriatric-specific problems have been documented to date. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving Alpostin.

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A New Method for Xenogeneic Bone Graft Deproteinization: Comparative Study of Radius Defects in a Rabbit Model. The generation of natural product-inspired scaffold diversity is an effective but challenging strategy to investigate the broader chemical space and identify promising drug leads. Downregulated CA8 sensitized cells to apoptotic stress induced by staurosporine and cisplatin, suggesting a specific role of CA8 to protect cells from stresses. Fourteen patients with complex fractures or post-traumatic sequelae and extensive bone defects requiring distal femur replacement were analysed retrospectively. Silver staining using acidic silver nitrate solution is preferred, due to easy preparation and good storage stability of the reagents. This series of letters outlines the response from MA Healthcare, key opinion leaders, and industry to the news that the Government is planning to introduce a generic project for wound dressings, limiting products to three main suppliers. Multiparametric Ultrasound (MPUS) Imaging: Terminology Describing the Many Aspects of Ultrasonography.

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Quantitative susceptibility mapping in patients with systemic lupus erythematosus: capecitabine tab 500mg detection of abnormalities in normal-appearing basal ganglia. Demand characteristics versus dissonance reduction as determinants of failure-seeking behavior. MOR in the CNS are involved in psychological stress-induced aggravation of allergic airway inflammation. Hypoxic-ischaemic encephalopathy is associated with development of cerebral palsy and cognitive disability later in life and is therefore one of the fundamental problems in perinatal medicine. This paper is concerned with the construction of optimal filters for smoothing the photon noise that arises under low-light conditions in vision and under low-dose or short-exposure conditions in nuclear medicine.

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Small incision guarded hydroaspiration is a minimally invasive surgical technique for resection of select small iris lesions. However, there has been no systematic exploration of whether chromosomal instability generated as a result of deregulation of the mitotic checkpoint pathway, a frequent characteristic of solid tumours, has any effect on oncogene addiction. Birth weight of the Bengali new born: effect of the economic position of the mother. A missense mutation in KRT14 causing a dermatopathia pigmentosa reticularis/Naegeli-Franceschetti-Jadassohn phenotype. Obesogenic environment in families with high incomes need to be revealed. Many older adults are concerned about memory changes with age and consequently seek ways to optimize their memory function. The results support the hypothesis that species tolerant to habitat fragmentation detect and colonize new habitat faster than those intolerant to habitat fragmentation. Patients with severe CAD undergoing PCI for NSTEACS are at high risk for recurrent adverse events.

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Metastatic albenza medication metaplastic breast carcinoma mimicking pulmonary squamous cell carcinoma on fine-needle aspiration. Although titration of the infusion with occasional pauses of administration may be needed, excessive hypotension was not noted. Availability of transgenic varieties with antifungal traits is extremely valuable as a breeding tool. Gas exchange responses of Chesapeake Bay tidal marsh species under field and laboratory conditions. However, a moderate association persists for some measures, and it is recommended that researchers continue to test for this relationship when generating anchor-based MID values from change scores. PTC cell line TPC-1 with stable transfection of CCDC67 was used to investigate the functions of CCDC67. Twelve-year mortality in HIV-infected patients receiving antiretroviral therapy: the role of social vulnerability. The ubiquitination state of Tat was not seen to increase in the presence of NC, suggesting the proteasomal degradation was independent of ubiquitination.

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Observation of interprofessional collaborative practice in primary care teams: An integrative literature review. The technique of additional visual feedback has been shown to significantly decrease the center of pressure (CP) displacements of a standing subject. Cystic fibrosis (CF) is the most common severe, autosomal recessive disease in Caucasians. Cognition is a robust predictor of functional competence among older individuals with schizophrenia, regardless of medical burden. A lipopeptide based on the M2 and HA proteins of influenza A viruses induces protective antibody.

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To investigate the long-term results of ABO-incompatible (ABOi) kidney transplantation in a single center in Greece. We previously showed that photoablative laser therapy followed by multiple photodynamic cycles (PAPD) after scaling/root planing (SRP) improved healing of periodontitis patients as compared with conventional SRP after 1-year follow-up. Erythrocyte volume distribution curves: a parameter for evaluating erythrocyte preparations. Neuropeptide Y did not affect basal-or isoproterenol-stimulated force of contraction and did not inhibit forskolin-stimulated adenylate cyclase activity. Viability, fluorescence (particle volume), photometric, viral RNA, and particle number penetration of MS2 bacteriophage through filter media used in three different models of respirators were compared to better understand the correlation between viability and physical penetration. The results are interpreted as indicating the presence of a hydrogen bond from the carrier to the hydroxyl group at C-3 of d-glucose. Determinant role of testosterone in the pathogenesis of urolithiasis in rats.

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