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Anatero (Anastrozole)
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Anatero

Anatero lowers estrogen levels in the body, particularly the form of estrogen known as estradiol. Many breast tumors display estrogen receptors on cell surfaces. When these receptors are bound to estrogen it is thought that cell growth and thus tumor growth are stimulated.

Other names for this medication:
Altraz, Altrol, Anabrez, Anastrocare, Anastrozole, Anatero, Anazol, Armilon, Armotraz, Femistra, Femitraz, Qubol, Redest, Rimidex, Stazonex, Xenosoul

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Uroxatral, Tofranil, Micardis, Exelon, Medrol, Sovaldi, Adipex, Danocrine, Priligy, Arzomicin, Promacot, Pandom, Zelor, Etham, Difra,

Also known as: Anastrozole

Description

Anatero is approved to treat certain types of breast cancer in women who’ve gone through menopause.

What breast cancer is

Breast cancer develops when cells in your breast start to grow and multiply (make more cells) more quickly than usual. With most breast cancers, the abnormal cells are encouraged to grow by the hormone estrogen.

If your breast cancer is stimulated by hormones, such as estrogen, certain tests will show that the cancer cells have receptors (attachment sites) for those hormones. This type of breast cancer is called hormone receptor-positive (HR+).

HR+ cancers can be treated with hormone therapies that lower the estrogen level in your body. And because most breast cancer is HR+, hormone therapies are also sometimes used to treat breast cancer whose receptor status isn’t known.

What Anatero does

Anatero is a hormone therapy that’s used to treat certain forms of breast cancer. It’s a type of drug called an aromatase inhibitor. Anatero works by stopping (inhibiting) the action of an enzyme called aromatase. (Enzymes are certain proteins that help chemical reactions to happen inside your body.)

The aromatase enzyme makes estrogen out of steroid hormones in your body, such as testosterone. Aromatase is found in various tissues, including your brain, fat, and skin.

Before menopause, estrogen is mainly produced by your ovaries. And just a small amount is made by the aromatase enzyme. But after menopause, your ovaries stop producing estrogen. At that point, the aromatase enzyme is the main way that your body makes estrogen. (And in men, estrogen is also mainly produced by the aromatase enzyme.)

By stopping aromatase from working, Anatero lowers the amount of estrogen in your body. This helps to stop estrogen from encouraging breast cancer to grow and spread.

How long does it take to work?

Anatero will start working soon after you begin taking it. But you won’t be able to notice this. Your doctor may order different kinds of tests during your treatment to check and see if the drug is working for you.

Dosage

The following information describes Anatero dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Drug forms and strengths

Anatero comes as 1-mg tablets that are taken by mouth.

Dosage for breast cancer

The usual dosage of Anatero for breast cancer is one tablet taken once a day. It’s best to take your dose at the same time each day.

What if I miss a dose?

If you forget to take a dose of Anatero, take the missed dose as soon as you remember. However, if it’s almost time for your next dose, just skip the missed dose and take your next dose as usual. Don’t take two doses together to make up for a missed dose.

To help make sure that you don’t miss a dose, try setting a reminder on your phone. A medication timer may be useful, too.

Will I need to use this drug long term?

Anatero is meant to be used as a long-term treatment for breast cancer. If you and your doctor determine that Anatero is safe and effective for you, you’ll likely take it long term.

The length of time that you’ll take this drug depends on the type of cancer you’re using it to treat. Below we describe the typical length of time that Anatero is given. But to know for sure how long you should take Anatero, talk with your doctor.

For advanced breast cancer

If you’re taking Anatero to treat advanced breast cancer, you’ll usually take the drug for as long as your doctor feels this treatment is right for you. (With advanced breast cancer, the cancer has either spread to nearby areas or lymph nodes, called locally advanced breast cancer, or spread to other parts of your body, called metastatic breast cancer.)

For early breast cancer

If you’re taking Anatero as adjuvant treatment of early breast cancer, you’ll usually take the drug for at least 5 years. Adjuvant treatment is used to lower the risk of your breast cancer coming back or spreading after it’s already been treated with surgery. (With early breast cancer, the cancer hasn’t spread out of either your breast or the lymph nodes in your armpit.)

It’s not currently known if Anatero should be continued after these 5 years. And if so, it’s not known for how long after the first 5 years it should be taken.

Some studies found that breast cancer is less likely to come back if an aromatase inhibitor is taken for an additional 5 years after the first 5 years of adjuvant therapy. (Aromatase inhibitors are a class of medications.) With this approach to treatment, the drug would be taken for a total of 10 years. However, other studies didn’t show a benefit for extending the treatment beyond 5 the usual years.

In addition, one recent study found that taking Anatero for a total of 10 years didn’t provide any more benefit than taking it for a total of 7 years.

How long you take Anatero for early breast cancer will depend on how likely your breast cancer is to come back. It will also depend on your risk of side effects from treatment.

Overdose

If you overdose Generic Anatero and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Anatero are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Anatero can interact with several other medications.

Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works. Other interactions can increase side effects or make them more severe.

Anatero and other medications

Below are lists of medications that can interact with Anatero. These lists do not contain all the drugs that may interact with Anatero.

Before taking Anatero, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Anatero and tamoxifen

Like Anatero, tamoxifen is a hormone therapy that’s used to treat breast cancer. But taking tamoxifen with Anatero can lower the amount of Anatero in your body. This can make Anatero less effective for you.

Because of this interaction, you shouldn’t take tamoxifen with Anatero. However, if recommended by your doctor, it’s fine to take Anatero after you’ve finished taking tamoxifen.

Anatero and drugs that contain estrogen

Taking Anatero with drugs that contain estrogen could make Anatero less effective for you. Because of this, you shouldn’t take these types of drugs while you’re using Anatero.

Examples of drugs that contain estrogen include:

  • hormone replacement therapy (HRT)
  • vaginal estrogen products, such as creams and tablets
  • birth control medications, such as pills, patches, and vaginal rings
If you have questions about using medications that contain estrogen with Anatero, talk with your doctor.

Anatero and herbs and supplements

There aren’t any herbs or supplements that have been specifically reported to interact with Anatero. However, you should still check with your doctor or pharmacist before using any of these products while taking Anatero.

For example, it’s possible that supplements such as red clover or wild yam could make Anatero less effective. (These supplements are used by some women to reduce menopausal symptoms, such as hot flashes.)

This interaction is possible because these supplements contain phytoestrogens, which are weak estrogen-like substances found in certain plants. There isn’t enough information available to say for sure whether taking phytoestrogens can affect your breast cancer treatment or not.

Be sure to talk with your doctor before taking any herbs or supplements with Anatero.

Anatero and foods

There aren’t any foods that are known to interact with Anatero. Talk with your doctor to find out if there are any foods you should avoid during Anatero treatment.

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AMLR was found to be impaired in patients with advanced cancer (stages III and IV), whereas normal values were found in the early stages of the disease (stages I and II). Age alters expression and inducibility of heme oxygenase isozymes in mice. A new phenolic, (4-hydroxy-2-isopropylphenyl)ethanoic acid and a new lignan, epi-calocedrin were obtained from the roots of Juniperus chinensis Linn. Cleavage of a 100 kDa membrane protein (aggregin) during thrombin-induced platelet aggregation is mediated by drug xanax side effects the high affinity thrombin receptors. The lymphoid lines CCRF-CEM and Daudi did not express PM-81 but HSB-2 was positive. Mutational spectrum of the ZEB1 gene in corneal dystrophies supports a genotype-phenotype correlation.

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This study assesses whether cost and quality imprinting can be detected within the 3,436 Hospital Service Areas (HSAs), 82.4 percent of which have only 1 teaching hospital, and whether sponsoring institution characteristics are associated. Green tea proanthocyanidins cause impairment of hormone-regulated larval development and reproductive fitness via repression of juvenile hormone acid methyltransferase, insulin-like peptide and cytochrome P450 genes in Anopheles gambiae sensu stricto. These data indicate that a serotonin-, but not a naloxone-sensitive opiate mechanism, may be relevant for aspirin-mediated antinociception. Projection of tooth pulp and oro-facial afferents to neurons in the cortical somatosensory area in the cat. Large cell transformation (LCT) of mycosis fungoides (MF) is associated with an aggressive iv protonix pediatric dosing clinical course, poor overall survival (OS), and variable CD30 expression. Items selected through a focus group and interviews were piloted on 180 self-identified gay or other MSM via an online questionnaire. The authors describe a strategy for systematic planning of simulation-based training that incorporates knowledge, skills, and attitudes as defined by the Quality and Safety Education for Nurses (QSEN) initiative. Since lindane interacts specifically with calcium transport and can induce an increase in cytoplasmic calcium, the strong effect of lindane on ciliary beat is probably correlated with a modification of the calcium balance of the cell. We now report that Vstat120 binding to CD36 on MVECs activates a caspase-mediated pro-apoptotic pathway, and this effect is abrogated by histidine-rich glycoprotein (HRGP). Initial-velocity kinetics of succinoyl-coenzyme A-3-oxo acid coenzyme A-transferase from sheep kidney.

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