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Anatram (Tramadol)

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Anatram is a pain medicine similar to an opioid. It acts in the central nervous system (CNS) to relieve pain. Anatram is used to treat moderate to severe pain in adults. The extended-release form of Anatram is for around-the-clock treatment of pain. This form of Anatram is not for use on an as-needed basis for pain.

Other names for this medication:
Accupain, Acema, Atdol, Avdol, Combitram, Cradol, Damol, Dolodol, Drobit, Gemodol, Haledol, Jpdol, Kevtram, Medol, Nobligan, Nopidol, Nosdol, Opidol, Opigesic, Painadol, Paxmax, Radol, Rybix, Sigmadol, Spasteez, Standol, Taramol, Taxidol, Traceta, Tramabit, Tramache, Tramadex, Tramadol, Tramaflam, Tramakind, Tramazol, Trambax, Tramed, Tramest, Tramot, Trandol, Transic, Tromar, Trydol, Ultraspas, Ultrax, Vardol, Victadol, Zytram

Similar Products:
Naprosyn, Thorazine, Plavix, Amoxil, Terramycin, Adalat, Fasigyn, Cardiogoxin, Kelvin, Perizor, Nobligan, Glipimet, Bunase,

Also known as: Tramadol


Anatram ER is an pain medicine similar to an opioid. This medicine is used to treat moderate to severe pain.

The extended-release form of tramadol is for around-the-clock treatment of pain. This form of tramadol is not for use on an as-needed basis for pain.


Usual Adult Dose for Pain:

Adults (17 years or older): 50 to 100 mg orally every 4 to 6 hours as needed for pain -For patients not requiring rapid onset of analgesic effect: Initial dose: 25 mg orally once a day; titrate in 25 mg increments every 3 days to reach a dose of 25 mg four times a day; thereafter increase by 50 mg as tolerated every 3 days Maximum dose: 400 mg per day.

Usual Adult Dose for Chronic Pain:

Extended-Release (ER): 18 years or older (tramadol-naive): 100 mg orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day For patients CURRENTLY receiving Immediate-Release (IR) Anatram: Initial Dose: Calculate 24-hour IR requirement and initiate with a total daily ER dose rounded down to the next lowest 100 mg increment orally once a day Conversion from OTHER Opioids: Discontinue all other around the clock opioid drugs prior to initiating therapy -Initial dose: 100 mg ER orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day.

Usual Geriatric Dose for Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Geriatric Dose for Chronic Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Pediatric Dose for Pain:

Anatram is not recommended for use in pediatric patients 17 years or older: See Adult Dose.

Detailed Anatram dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Anatram are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not drink alcohol. Dangerous side effects or death could occur.

Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

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The synthesis and odour properties of the new santalol analogue, methyl-beta-santalol, are described. The flaps regained sensation pertaining to the chest in the early stage, and complete sensation pertaining to the neck appeared 6 months after surgery. The expression of VEGF in the inner enamel epithelium (ameloblasts) would seem to depend on the stage of differentiation, leading us to deduce that VEGF and its respective receptor are expressed in dental germ and that induce alterations not only on the vascularization, but also on the inner epithelium activation and then on dental enamel development, respectively on cap and bell stages of embryogenesis. For the immune system to recognize and remove dying cells efficiently, professional phagocytes use a variety of mechanisms that distinguish healthy cells from dying cells. In particular, Myotis capaccinii reacted equally to the feeding buzzes of conspecifics and to ecologically more similar heterospecifics. The analysis of correlations between clinical and computer tomographical symptoms of DE on the one hand and the indices of central hemodynamics, head blood circulation and presence of atherosclerosis of head arteria on the other hand was performed. The expression of AT(1)R in VSMCs could be upregulated initially after treatment with Ang II, then decreased gradually. Infrared laser vaporization thinned the oval window neomembrane to identify the precise depth and margins of the oval window, the presence of residual stapes footplate, and finally, the relationship of the prosthesis to the fenestra into the vestibule. The internal temporal dimension appeared to be directional and reflected the chronological distance between everyday events.

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A method is described to perform combined immunohistochemistry and in situ hybridization in mouse brain sections. No variation in PPI was detected in any of the test groups when compared with controls, whatever the dosage and the treatment. Physician-specific gaps from our systematic review were prioritized by consensus meeting participants in two rounds, which involved the rating, discussion, and re-rating of gaps. The difference in the antihistaminic action of salicylic acid and sodium hydrocarbonate. The cantilever probes mounted on the probe scanners are attached to inertia sliders, which allow independent control of the probe positions. Association of gastric cancer incidence with MDR1 gene polymorphism in an ethnic Iranian population. The instantaneous response of the collateral circulation to isometric physical exercise in patients with non-occlusive coronary artery disease (CAD) is not known.

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This cross-sectional study included 50 hepatitis B patients tested for IgA anti-endomysial antibodies (EMAs) and tissue anti-transglutaminase (TTG) between August 2011 and September 2012. Low birthweight: more than a single hit malady of the first months of life. Males possess femoral glands on the hind legs, which recently have been shown to contain volatile compounds used in communication as pheromones. This procedure results in the energy-conserving dynamics for a closed system. Periodic breathing, arterial oxyhemoglobin saturation, and heart rate during sleep at high altitude.

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The final data were weighted according to the census of metropolitan areas and by gender, on the basis of Canadian population statistics. The results showed that these cells lack P53 and Bax protein expression, and strong peroxidase activity was confirmed in the nuclei of the cells. Role of oceanic air bubbles in atmospheric correction of ocean color imagery. To determine which drug-eluting stents are more effective in acute myocardial infarction (MI) patients with chronic kidney disease (CKD). The secondary end point was to evaluate the healing time of the lesions. In this work, we present an electromechanical model of the heart, which takes into account the interaction between ventricles, pericardium and atria and allows to reproduce the AVPD. Recently, ligands for the nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPARgamma) have exhibited promise in the treatment of CRC. Fasciotomy worsens the amount of myonecrosis in a porcine model of crotaline envenomation.

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Low expression of centrosomal protein 78 (CEP78) is associated with poor prognosis of colorectal cancer patients. Specific, local antivenins are available against only two of the species, while against others regional or European preparations are used. Direct detection of vanA and vanB genes in clinical specimens for rapid identification of vancomycin resistant enterococci (VRE) using multiplex PCR. The Gbetagamma subunit plays a central role in G-protein signaling. T-tests and Mann-Whitney two-sample tests were used to determine statistical significance of differences. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values were obtained within the posterior part of the intraorbital optic nerves. Simultaneous determination of a potassium channel opener and its metabolite in rat plasma with column-switching liquid chromatography using atmospheric pressure chemical ionisation.

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Data pooling was omitted due to the impossibility of combining outcome parameters. Entries in prison and community medical records were used by a three-member expert panel to establish the likelihood of primary HIV infection and its possible timing and location. The G551D mutation is reasonably common in the CF patient population and produces a CFTR protein that localizes normally to the plasma membrane, but fails to open in response to cellular cues. The factor that determined the severity of PNP course was the age of DM onset. This pragmatic attitude in selecting the control group may explain the difference observed with the ACR criteria in terms of sensitivity and specificity. Effect of IL-12 on canine dendritic cell maturation following differentiation induced by granulocyte-macrophage CSF and IL-4. In the next step these helices would slide away from each other, adopting a parallel orientation to the membrane, and would rotate to maximize the interaction between their hydrophobic residues and the lipid bilayer. Heavy-tailed prediction error: a difficulty in predicting biomedical signals of 1/f noise type.

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The impact of right atrial ischemia on inferior myocardial infarction with extension to right ventricle: transesophageal echocardiographic examination. Using oxytetracycline-supplemented malt extract agar, yeasts were isolated from four commercially available Kombucha products and identified using conventional biochemical and physiological tests. The O6-methylguanine DNA methyltransferase (MGMT) enzyme is related with temozolomide (TMZ) resistance. Many ailments of the ankle joint that were previously treated through open approaches are today treated with arthroscopic techniques. The scrapie-induced gliosis in IL-1RI(-/-) mice was characterized by an attenuated activation of astrocytes in the asymptomatic stage of the disease and a reduced expression of CXCR3 ligands. Her medical history included gamma-knife therapy for clinical diagnosis with a suspicion of cerebral lymphoma. Our case shows that spontaneous resolution of a juvenile eosinophilic orbital pseudotumor is possible. The infrared echo measurement probes the time scales of the molecular motions that couple to a vibrational transition. Prophylactic perioperative administration of antibiotics has proved to be effective.

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The catadromous European eel (Anguilla anguilla L.) has suffered a dramatic decline in recruitment for three decades, necessitating a thorough assessment of the transcriptional effects of environmental pollutants on resident and migrating eels in natural systems. Intra-amniotic endotoxin causes chorioamnionitis and results in improved lung function after preterm delivery in sheep. To investigate the experiences and perceptions of adolescents who have experienced a recent pregnancy and undergone a termination of pregnancy. Thousands of defensin molecules bind with low micromolar affinity to a sensitive serotype, but only a low level of binding is observed to resistant serotypes. Orbital haematoma should be considered in the newborn with unilateral proptosis. Metalloproteinases (MMPs) are a family of enzymes involved in many physiological processes, such as skeletal development, wound healing, and scar formation, as well as carcinogenesis. Pleomorphic adenomas showed significantly lower KLK10 levels than control tissues. Reinforced stabilization of the noncollagenous domain-1 by noncovalent forces and the absence of Met-Lys cross-links. A unique case of dystrophic calcification in masseter: a diagnostic challenge. Eukaryotic initiation factor (eIF) 2B is a guanine-nucleotide exchange factor that plays a key role in the regulation of protein synthesis.


Is focused on a 10 mm perforation of sinus membrane occurred during preparation of the sinus window. The vertical component was not distributed uniformly over the whole hoof surface. We comprehensively review the anatomic and functional changes occurring post prostatectomy along with the reconstructive techniques and published outcomes of PRR. Compared with conventional open approach for aortofemoral bypasses performed concomitantly during this period, laparoscopic patients required fewer narcotics and a shorter in-hospital stay and earlier recovery. Analyses of the small-subunit (SSU) ribosomal DNA (rDNA) sequences from all representative families in the order (Trilosporidae, Kudoidae, Pentacapsulidae, Hexacapsulidae, and Septemcapsulidae) indicate that a revision of the taxonomy and nomenclature is warranted. Unprecedented eight-palladium(I) crown-cycle with metal-metal unsupported bonds.

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The reports of the series to date have been difficult to interpret and although the results are claimed to be equivalent or better than those associated with a traditional approach a careful examination of the literature and comparison with the best results previously reported does not presently support this. Effect of Kupffer cell inactivation on ethanol-induced protein adducts in the liver. Marginal keratitis associated with administration of filgrastim and sargramostim in a healthy peripheral blood progenitor cell donor. Case-series study was conducted in National Cancer Institute, Cairo University over the period from July 2005 - January 2009 which included 23 patients with clinically T-1 N0, T-2 N0 invasive squamous cell carcinoma of buccal mucosa and the vermilion border of the lower lip. We observed a marked increase in the total number of cells secreting immunoglobulins of all isotypes as early as on the 3rd day post-infection and the peak of secretion occurred on the 7th day. Isolation and identification of hematopoietic stem cell-stimulating substances from Kampo (Japanese herbal) medicine, Juzen-taiho-to.

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Diagnosis of the AIBSE syndrome was based on clinical findings including an enlarged blind spot without corresponding ophthalmoscopic changes of the ocular fundus and with depressed multifocal electoretinograms. Cutting edge: IL-4 production by mast cells does not require c-maf. A practical, systematic laboratory approach to the study of the peripheral circulation. Synthesis, antioxidant and DNA cleavage activities of novel indole derivatives. The use of lignocellulosic materials for second generation ethanol production would give several advantages such as minimizing the conflict between land use for food and fuel production, providing less expensive raw materials than conventional agricultural feedstock, allowing lower greenhouse gas emissions than those of first generation ethanol. Diurnal changes in gas exchange and carbon partitioning in needles of fast- and slow-growing families of loblolly pine (Pinus taeda). RSVH rates were low in DS following prophylaxis and hazards were similar to those found in SI and MI. Sprague-Dawley rats were exposed to transient (90 min) middle cerebral artery occlusion (MCAO) and evaluated after 1 day of survival. It is possible that CBPb01 interconnects through its GlcNAc structure, subsequently forming complexes.

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Determination of the dynamics of specific cell populations in vivo is essential for the development of cell-based therapies. Under aqueous conditions, the films swell and the degree of swelling depends on the nanocomposite composition and film structure. In MSO-pretreated rats there was a significant decrease in the survival rate when compared to untreated ischemic rats. In contrast, grade has shifted heavily toward moderate differentiation. By cell imaging, we have previously observed the differential compartmentalization of transcription factors and histone modifications at the nuclear periphery in mouse C2C12 myoblasts.

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Cells were treated by a diode laser (678 nm) with 800 and 1600 mW for 0.186 second. High-throughput molecular identification of fungi has greatly progressed our understanding about the diversity of mutualists, saprotrophs, and pathogens. Two such important properties are their mechanical stability and malleability. Results revealed a significant effect of sexual arousal on rhythm synchronization. We investigated the antitumor effects of gene transfer of ICAM-2 using the adenovirus vector AdICAM-2 in vitro and in vivo. Further investigation of these relationships is warranted to see if DHCQ may be introduced as a new antirheumatic drug. From 2007 to 2011, 102 patients with invasive cervical cancer underwent an abdominal radical hysterectomy. Options to avoid the second surgical site: a zantac drug generic and brand name review of literature.

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Primary melanomas evolve from melanocytes or from precursor lesions through two stages: the radial and vertical growth phases. Sequence-based analysis of the microbial composition of water kefir from multiple sources. Plasma D-dimer concentration was significantly higher in severe, but not in mild preeclampsia compared to the controls. Localized scleroderma may invade into the subcutaneous fat layer and cause permanent functional disability. Mental well-being has aroused interest in Europe as an indicator of population health. Multiple regression analyses were performed with gestational age as outcome variable, and multilevel analysis with birthweight as outcome variable. We report a case of atypical JCPyV encephalopathy associated with cerebral venous sinus thrombosis and disseminated primary JCPyV infection originating from the kidney allograft. sigma PBDE concentrations ranged between 21 and 1650 pg/g fresh weight in the edible tissues of five species of fish and one shellfish species. Taken together, these findings indicate 6-HMA is a major active constituent from the roots of B.

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To describe the clinical, neurophysiological, and histological features of a pathologically unique tumor involving the sciatic nerve. General reduction of dental caries and patient interest in dental aesthetics have resulted in the development of new restorative materials and techniques. The two systems responded similarly to diethyldithiocarbamate inhibition and acetone inhibition/induction of cytochrome P-450 mediated metabolism. The demonstration of size dependent room temperature H(2) sensing paves the ways to fabricate the room temperature metallic and metal-metal oxide semiconductor sensor by tuning the size of metal catalyst in mixed systems. Additionally, removing stasis with scraping should be combined with regulating qi and blood to enhance the therapeutic effect. The incidence of sperm aneuploidy, semen parameters, fertilization rate, pregnancy characteristics, and rate of neonatal malformations were determined.

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The precise identification, to individual NCBI database entries, of a number of glutathione S-transferases and cathepsin Ls from F. Cultured neonatal rat cardiomyocytes were treated with the specific AMPK activator 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) and the specific AMPK antagonist Compound C, and then stimulated with phenylephrine (PE). A further option is the combination of enantiomeric with isotope fractionation as complementary indicator for enzymatic bond cleavage reaction governing biodegradation. In this study, the refinement of purification techniques led to large quantities of PLM being extracted from Candida albicans cells. Although no specific treatment can guarantee a sustained remission of this disease, surgery for loco-regional lesions can result in long-term symptomatic control and restoration of function. However, similar hybridization signals were also observed in the fibrous inflammatory area using mock hybridization for endogenous biotin. Variations in biliary anatomy appear to be the rule rather than the exception. Short-term immunotherapy: a prospective, randomized, double-blind, placebo-controlled multicenter study of molecular standardized grass and rye allergens in patients with grass pollen-induced allergic rhinitis. Nucleophilic substitution of 1,6,7,12-tetrachloro perylene bisimide (PBI) with n-butanethiol provided a novel, highly twisted PBI bearing four sulphur coordination sites at the bay positions, from which silver and palladium complexes were prepared.

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Tyrphostins, specific inhibitors of protein tyrosine kinase (PTK), block the signaling events induced by TNF and NO production. Five years after the operation, the patient is well, without evidence of recurring disease, based on clinical investigation and modern imaging techniques. All patients underwent superselective angiography and attempted embolization with Guglielmi detachable coils (GDCs). Rapid and improved method for windowing eggs accessing the stage X chicken embryo. Oxidative stress is viewed as a critical pathogenic factor implicated in the initiation, development, and progression of most renal diseases.

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Expression of pleiotrophin in hepatic nonparenchymal cells and preneoplastic nodules in carbon tetrachloride-induced fibrotic rat liver. It is known the genetic and neuroimaging findings, but there are few studies about its histopathology. Therefore, these results suggest that PCBs have the potential for dopaminergic neurotoxicity, which may be related with the PCBs-mediated alteration of NO production originating from nNOS at least in part. We performed a multicentre, randomized, placebo-controlled trial to investigate the clinical efficacy and side-effect profile of a humanized monoclonal antibody to E-selectin, CDP850, in fasigyn tablet uses the treatment of moderate to severe chronic plaque psoriasis. More recently MI and its variants have also been used in the prediction of contacts between proteins (inter-protein). Two systems have recently received FDA approval for routine use as quality control (rescreening) devices. The experimental observations of changes in NO imply a corresponding switching in endogenous ROS levels and support theoretical predictions of an irreversible change to damagingly high levels of endogenous ROS when PD risks are sufficiently large. This study compared the placement and functions of these two devices. To determine the relationships between visual and hearing impairment and subsequent functional dependence and mortality among community-dwelling older persons. I find the optimum retardance for the rotating retarders to be 127 degrees.

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