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Combutol (Ethambutol)
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Combutol

Combutol is a medication primarily used to treat tuberculosis. It is usually given in combination with other tuberculosis medications, such as isoniazid, rifampicin and pyrazinamide. It may also be used to treat Mycobacterium avium complex, and Mycobacterium kansasii. It is taken by mouth.

Other names for this medication:
Althocin, Amiobutols, Bacbutol, Combutol, Corsabutol, Dexambutol, Ebutol, Esanbutol, Etambutol, Etapiam, Etham, Ethambutol, Ethambutolo, Ethambutolum, Etibi, Fiambutol, Macox, Miambutol, Mycobutol, Niazitol, Oributol, Pulna, Rifafour, Rimstar, Santibi, Sural, Themibutol, Tibitol, Tibutol, Turresis

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Also known as: Ethambutol

Description

Combutol is a prescription medication used to treat tuberculosis (TB). Combutol belongs to a group of drugs called antimycobacterial antibiotics. TB is caused by a certain bacteria. Combutol works by stopping the bacteria from forming a cell wall, which kills the bacteria.

This medication comes in tablet form. It is taken once a day with or without food.

Common side effects of Combutol include loss of appetite, upset stomach, and numbness or tingling in hands and feet.

Dosage

Initial Treatment: In patients who have not received previous antituberculous therapy, administer Combutol 15 mg/kg (7 mg/ lb) of body weight, as a single oral dose once every 24 hours. In the more recent studies, isoniazid has been administered concurrently in a single, daily, oral dose.

Retreatment: In patients who have received previous antituberculous therapy, administer Combutol 25 mg/kg (11 mg/lb) of body weight, as a single oral dose once every 24 hours. Concurrently administer at least one other antituberculous drug to which the organisms have been demonstrated to be susceptible by appropriate in-vitro tests. Suitable drugs usually consist of those not previously used in the treatment of the patient. After 60 days of Combutol administration, decrease the dose to 15 mg/kg (7mg/ lb) of body weight, and administer as a single oral dose once every 24 hours.

During the period when a patient is on a daily dose of 25 mg/kg, monthly eye examinations are advised.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature (20 to 25 degrees C [68 to 77 degrees F]) away from light and moisture. Keep this and all medicines out of the reach of children.

Side effects

The most common side effects associated with Combutol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Be sure to use Combutol for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Long-term or repeated use of Combutol may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

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