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Depakote (Divalproex)

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Depakote is used to treat seizure disorders, certain psychiatric conditions (manic phase of bipolar disorder), and to prevent migraine headaches. It works by restoring the balance of certain natural substances (neurotransmitters) in the brain.

Other names for this medication:
Biproate, Desval, Dilex, Divaa, Divalex, Divalprid, Epilex, Epirate, Epsoval, Genval, Napilex, Nepilex, Spikalon, Trival, Valance, Valcontin, Valep, Valop, Valowin, Valpex, Valpip, Valporate, Valporil, Valprid, Valprosh, Valrate, Velpo, Velze, Vinchorate

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Also known as: Divalproex


Depakote ER comes in different pill forms that are for different uses.

Depakote ER tablets and capsules are used to treat seizures in people with epilepsy who are at least 10 years old. This medicine tablets are sometimes used together with other seizure medications.

Depakote ER tablets are also used in adults to prevent migraine headaches, or to treat manic episodes related to bipolar disorder (manic depression).


Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Drink plenty of water while you are taking this medication. Your dose may need to be changed if you do not get enough fluids each day.

Swallow the capsule or tablet whole and do not crush, chew, break, or open it.

If you cannot swallow a sprinkle capsule whole, open it and sprinkle the medicine into a spoonful of pudding or applesauce. Swallow the mixture right away. Do not save it for later use.

You may need frequent blood tests.

If you need surgery, tell the surgeon ahead of time that you are using Depakote Sprinkles.

In case of emergency, wear or carry medical identification to let others know you use Depakote Sprinkles.

Do not stop using Depakote Sprinkles suddenly, even if you feel fine. Stopping suddenly may cause a serious, life-threatening type of seizure. Follow your doctor's instructions about tapering your dose.

Store at room temperature away from moisture and heat.

Detailed Depakote Sprinkles dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Depakote are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Drinking alcohol may increase certain side effects of divalproex sodium.

Avoid driving or hazardous activity until you know how Depakote ER will affect you. Your reactions could be impaired.

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