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Desyrel (Trazodone)
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Desyrel

Desyrel is used to treat depression. It is thought to work by increasing the activity of serotonin in the brain. Desyrel is an antidepressant. This medicine is available only with your doctor's prescription.

Other names for this medication:
Depryl, Tazodac, Tragon, Trazalon, Trazan, Trazaril, Traze, Trazodep, Trazodone, Trazolite, Trazonil, Trittico, Zopotol

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Also known as: Trazodone

Description

Desyrel is an antidepressant that is used to treat major depressive disorder.

Dosage

This section provides information on the proper use of a number of products that contain trazodone. It may not be specific to Desyrel. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.

To lessen stomach upset and to reduce dizziness and lightheadedness, take the regular tablet with or shortly after a meal or light snack.

Take the extended-release tablet at the same time each day, preferably at bedtime, without food.

The tablet can be swallowed whole or given as a half tablet by breaking the tablet along the score line. Do not break the tablet unless your doctor tells you to. Do not crush or chew the tablet.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For depression: For oral dosage form (extended-release tablets): Adults—At first, 150 milligrams (mg) per day as a single dose. Your doctor may adjust your dose as needed. However, the dose is usually not more than 375 mg per day. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults—At first, 150 milligrams (mg) per day, given in divided doses. Your doctor may adjust your dose as needed. However, the dose is usually not more than 400 mg per day. Children—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal when Desyrel is taken with alcohol, barbiturates such as phenobarbital, or sedatives such as diazepam (Valium).

Overdose symptoms may include extreme drowsiness, vomiting, penis erection that is painful or prolonged, fast or pounding heartbeat, seizure (black-out or convulsions), or breathing that slows or stops.

Storage

Store at room temperature between 15 and 30 degrees C (59 to 86 degrees F) away from moisture and heat. Protect from light. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Desyrel are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Desyrel if you are allergic to it.

Do not use Desyrel if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others.

After you stop taking Desyrel, you must wait at least 14 days before you start taking an MAOI.

Tell your doctor if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with Desyrel could cause a serious condition called serotonin syndrome.

Tell your doctor if you have ever had:

liver or kidney disease; heart disease, or a recent heart attack; a bleeding or blood clotting disorder; seizures or epilepsy; narrow-angle glaucoma; long QT syndrome; drug addiction or suicidal thoughts; or bipolar disorder (manic depression).

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Taking Desyrel during pregnancy could harm the baby, but stopping the medicine may not be safe for you. Do not start or stop Desyrel without asking your doctor.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of trazodone on the baby.

Ask a doctor if it is safe to breastfeed while using this medicine.

Desyrel is not approved for use by anyone younger than 18 years old.

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