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Motrin (Ibuprofen)

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Motrin is an everyday painkiller for a range of aches and pains, including back pain, period pain, toothache. It also treats inflammation. It treats inflammation such as strains and sprains, and pain from arthritis. It's available as tablets and capsules, and as a syrup that you swallow.

Other names for this medication:
Advil, Alfam, Arthophen, Emflam, Genpril, Ibucon, Ibuflamar, Ibugard, Ibugin, Ibuprofen, Iburin, Ibusynth, Inflapen, Ipecee, Lederflam, Lumbril, Maxofen, Mebufen, Methopar, Methoprofen, Procold, Pyrofen, Robiflam, Tabalon, Tidifen, Treza, Xtragesic

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Prevacid, Luvox, Elocon, Viramune, Sovaldi, Motrin, Rebetol, Lanoxin, Flomax, Ethiflox, Fexolast, Ortel, Maalox, Apomatine, Amurol, Ditensor, Hypetin, Noviken, Rolacin,

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Also known as: Ibuprofen


Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain, and helps to relieve symptoms of arthritis (osteoarthritis, rheumatoid arthritis, or juvenile arthritis), such as inflammation, swelling, stiffness, and joint pain. This medicine does not cure arthritis and will help you only as long as you continue to take it .

In addition, ibuprofen can be used to treat fever, menstrual cramps, and other conditions as determined by your doctor .

This medicine is available both over-the-counter (OTC) and with your doctor's prescription .


This section provides information on the proper use of a number of products that contain ibuprofen. It may not be specific to Motrin. Please read with care.

For safe and effective use of this medicine, do not take more of it, do not take it more often, and do not take it for a longer time than ordered by your doctor. Taking too much of this medicine may increase the chance of unwanted effects, especially in elderly patients .

When used for severe or continuing arthritis, this medicine must be taken regularly as ordered by your doctor in order for it to help you. This medicine usually begins to work within one week, but in severe cases up to two weeks or even longer may pass before you begin to feel better. Also, several weeks may pass before you feel the full effects of this medicine .

To lessen stomach upset, you may take this medicine with food or milk .

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets and suspension): For fever: Children over 2 years of age—Use and dose must be determined by your doctor. Children 6 months of age up to 2 years—Dose is based on body weight and body temperature, and must be determined by your doctor. For fever lower than 102.5 °F (39.2 °C), the dose usually is 5 milligrams (mg) per kilogram (kg) (about 2.2 mg per pound) of body weight. For higher fever, the dose usually is 10 mg per kg (about 4.5 mg per pound) of body weight. The medicine may be given every six to eight hours, as needed, up to 40 mg per kg per day. Infants younger than 6 months of age—Use and dose must be determined by your doctor . For menstrual cramps: Adults—400 milligrams (mg) every four hours, as needed. Children—Use and dose must be determined by your doctor . For mild to moderate pain: Adults and teenagers—400 milligrams (mg) every four to six hours, as needed. Children over 6 months of age—Dose is based on body weight and must be determined by your doctor. The dose usually is 10 milligrams (mg) per kilogram (kg) of body weight every six to eight hours, as needed, up to 40 mg per kg per day. Infants younger than 6 months of age—Use and dose must be determined by your doctor . For osteoarthritis and rheumatoid arthritis: Adults and teenagers—1200 milligrams (mg) up to 3200 mg per day divided into three or four equal doses. Children—Dose is based on body weight and must be determined by your doctor. The dose usually is 30 milligrams (mg) to 40 mg per kilogram (kg) of body weight per day, divided into three or four doses. Infants younger than 6 months of age—Use and dose must be determined by your doctor .


If you overdose Motrin and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Motrin overdosage: uncontrolled eye movements, blue color around lips, mouth, and nose, slow breathing, feeling lightheaded.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Children's Motrin dosage information

Side effects

The most common side effects associated with Motrin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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A single strain was grown in media containing incrementally varying ratios of (13)C(6) to (12)C(6) glucose, and it was found that (13)C incorporation shifted characteristic peaks to lower wavenumbers. We find that residence in a neighborhood that is perceived as noisy, unclean, and crime-ridden is associated with poorer self-rated physical health, even with controls for irregular exercise, poor diet quality, smoking, binge drinking, obesity and a host of relevant sociodemographic factors. Until the elastin/collagen supporting network is laid down these nascent septal walls are vulnerable to collapse against sac or duct walls during this transitional period. Recurrent coronary artery spasm during a non-cardiac surgical procedure. We have investigated, by comparative sequencing, the evolution of two hotspots of non-allelic homologous recombination on the Y chromosome that lie within paralogous sequences known to sponsor deletions resulting in male infertility. Although the l-projected density of states of CaS is in good agreement with previous first-principles calculations, the standard muffin-tin potential is inadequate to reproduce near-edge structures at both Ca and S K-edges in this system. To confirm the presence of EVs in the preparations, researchers have identified so-called EV marker proteins, including the tetraspanin family proteins and such cytosolic proteins as heat shock 70 kDa protein 4 (HSP70) and tumour susceptibility gene 101 (TSG101). The fiber taper is used both to efficiently pump the cavity and collect the cavity emission. The Ah receptor (AhR), a soluble cytosolic protein, mediates most of the toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related environmental contaminants.

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Epidemiological study of power lines and childhood cancer in the UK: further analyses. The explant model provides evidence for the involvement of macrophages and glial fibrillary acidic protein activation in human retinal angiogenesis and for the expression of monocarboxylate transporter type 1, which is likely to be important in the use of lactate in the hypoxic retina. After 21th years of age ophthalmological symptoms are observed in all patients. By studying the effects of gradient time, flow rate, temperature, final eluent composition, and column length on peak capacity, a protocol has been developed for the optimization of a separation of small molecules such as those seen in metabolomic studies. In contrast to the western series, acute arthritis in our series responded well to oral colchicine alone. Here, we developed multiplex targeted mass spectrometry assays for the simultaneous quantification of all 15 KLKs. Around this time last year, there were said to be about 40,000 managers in the NHS, and questions were asked in the media about what they all did. Upon hospitalization, risk assessment and prevention must be systematic.

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Further, the cooperativity of 8 and 9 in binding tartrate was also investigated, revealing little or no cooperativity with 8, but negative cooperativity with 9. Perhaps the most important advantages were the increased patient and caregiver confidence and independence, as well as the reduction in anxiety and hospital attendance. However, in the initial phase of aggregation, Ncad-1 cells aggregated more rapidly than cad7-29 cells. Microlaparoscopic conscious pain mapping in the evaluation of chronic pelvic pain: a case report. Acute myocardial infarction in the West Indies: early observations, current issues and future concerns. In contrast to our expectation, herbivore effects on plant community biomass were not influenced by productivity. Brief risk-reduction counseling in clinical settings for HIV pre-exposure prophylaxis. Simultaneous presence of pAB4/pAB8 in Pf (pAB48) and pAB4/pBBR1MCS-2 in Pf (pAB4BBR1MCS-2) reduced their respective copy numbers to nearly half. To estimate the frequency of mood and anxiety disorders and to assess memory and executive functions among a representative group of patients with episodic cluster headache (ECH) during the course of an acute episode.

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A case of bupropion overdose demonstrating the typical toxic syndrome is presented, together with a review of the literature and a discussion of the magnitude of the demand for bupropion and of the potential differences in presentation of overdoses in Australia. Over time, octogenarians undergoing primary percutaneous coronary intervention increased in number, age, and complexity. The patient underwent subtotal sternectomy, radical thymectomy, and reconstruction with biological mesh (Permacol). All patients showed improvements in quality of life (assessed using the EORTC QLQ-C30 questionnaire). Retrospective evaluation of partial parenteral nutrition in dogs and cats. It was found that the optimum separation condition for the analysis of these compounds was a buffer solution which contained phosphate, borate and sodium dodecyl sulfate (pH 9.2). Nutritive value of masau (Ziziphus mauritiana) fruits from Zambezi Valley in Zimbabwe.

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The aim of the present study was to compare the regulation of glucose uptake and lipolysis in adipocytes by insulin in control and LP offspring. Exploring the Impact of Information Seeking Behaviors of Online Health Consumers in the Arab World. To examine the impact of unfettered access to high quality fixed-imaging fluoroscopy in a vascular surgery practice. Event-related functional magnetic resonance imaging was used to measure developmental changes in the functional neuroanatomy subserving controlled lexical association. The aim of the review is to provide an overview of the recent development regarding physiological function of the K channels and the novel factors which modulate the K channels of the ASDN. At postnatal day 1 (P1), P3, P5, and P10, Wistar rat pups were released into constant darkness, and a 30-minute light pulse was administered during the subjective day or during the first or second part of subjective night. Expression of toll-like receptors in the fetal gut was examined by using RT-PCR. But so far we have learned that endogenous factors play an equal, if not a more important role, in the onset of this group of diseases. Patients who underwent cholecystectomies served as matched controls. The test based on morphological changes in KB cells was assayed with different toxins.

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Protease-activated receptor-2 activation improves efficiency of experimental ischemic preconditioning. Acoustic quantification of left ventricular diastolic parameters (filling rates) was less sensitive than Doppler in detecting these early diastolic abnormalities in both diseases. The present study demonstrates a potential role of proton therapy in decreasing the dose (and toxicity) to the critical structures in the irradiation of the spinal neuraxis in medulloblastoma/PNET. On the tapping task, left-hand tapping was slower than right-hand tapping. Comparative effects of ventricular assist device and extracorporeal membrane oxygenation on renal function in pediatric heart failure. Measurements were performed for stationary detectors and moving detectors using the beam tracking system.

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We present a case of transitional cell carcinoma of the bladder visualized by 99mTc-HMDP bone scintigraphy and suggest possible uptake mechanisms. The VO2max of South Indian children was lower than the predicted values available for North American children when prediction equations based on height were used. Presence of immunologically active fragments after proteolytic degradation of human gamma-globulin. A randomized, placebo-controlled trial of these subjects showed that the lactobacilli-dominant microbiota was restored in subjects with BV but not in controls, following 2 months of daily oral intake of Lactobacillus rhamnosus GR-1 and Lactobacillus fermentum RC-14. Automated enzymatic mitochondrial antibody assay for the diagnosis of primary biliary cirrhosis: applications of a routine diagnostic tool for the detection of antimitochondrial antibodies. Cigarette smoke can be divided into two phases, gas phase and particulate matter (tar). Alanine-scanning mutagenesis in the signature disulfide loop of the glycine receptor alpha 1 subunit: critical residues for activation and modulation.

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To investigate the antibiotic resistance genes inserted into class 1 and class 2 integrons in Acinetobacter baumannii (A. Sensitization required self-MHC I and indirect effects of IFN-alphabeta, which together upregulated the T-box transcription factor Eomesodermin, potentially enabling the T cells to rapidly transcribe CTL effector genes and behave like memory cells rather than naive T cells. The following detailed protocol can be applied to demonstrate the localization of GABA receptors in CNS neurons at the ultrastructural level. It appears that the decay of ImP is indicative of resistive fluid flow occurring primarily in the vasculature and other intraosseous channels such as lacunar-canalicular pores, and that SP represents the fluid flow in the smaller porosities, i.e., lacunar-canalicular system or even microspores. Manufacturing desire: the commodification of female sexual dysfunction. Connexin mutations have been identified in a number of genetically inherited channel communication-opathies.

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Our results indicate that there are large differences in the activity of methanotrophs in the wetlands of this region. Localization of the ventricular insertion site of concealed left-sided accessory pathways using ventricular pace mapping. The primary change in the lung in the positive control group was a significantly increased star volume, which was approximately threefold that of animals not treated with ovalbumin and the dexamethasone-treated group. However, measurement of 100 Hz phase angles was in good agreement with the capacitive changes predicted by the ECM and consistent with suggestions that this represents protein absorption on the electrode surface. This model provides a valuable and easy-to-set-up tool for preclinical studies of mast cell-inhibiting compounds. all patients had salivary melatonin concentrations determined utilizing a motrin 600 mg competitive enzyme immunoassay technique (ELISA). Dual inhibitors are drugs able to block both the COX and the 5-LOX metabolic pathways. Mathematical and numerical analyses revealed that the lateral inhibition did not amplify the signal difference between neighboring cells over the parameter ranges in which the spatial pattern of tip selection was realized. CCI caused a variety of unilateral motor deficits, which were characterized in detail by using the selected fine motor skill tests.

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The principles described here are applicable to assays for any biological material. This response is often characterized by the activation of a local hypersensitive reaction involving programmed cell death, which constrains proliferation of biotrophic pathogens. 2013 Pediatric Research, 74, 54-60) presents a semiempirical model for facile calculation of an action spectrum for bilirubin photochemistry in vivo using the most current knowledge of the optics of neonatal skin. Because there exists a risk of malignancy in a substantial portion of adult intussusception cases, resection should be performed in a manner consistent with the oncological principles. Follow-up interviews were completed 30 and 60 days post hospital discharge. Transfection of plasmid DNAs to NIH3T3 fibroblasts resulted in a marked repressive effect of NRSE on BDNF promoter I- or c-fos promoter-mediated transcription. Although in routine clinical practice an improvement in HbA1c results in better lipid values. Although the majority of reported pericardial teratomas have been excised successfully in the postnatal period, the outcome of prenatally diagnosed pericardial teratomas remains less favorable. The study of thyroid function in patients with cardiac failure of unknown origin and resistant to therapy, should be bone in mind.

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Modulating osteogenesis of mesenchymal stem cells by modifying growth factor availability. Many, but not all, studies have suggested that reduced availability of NO contributes to the increased pulmonary vascular resistance that occurs in experimental models and in humans with pulmonary hypertension. This system, combined with experience, can reduce the greater labor intensity sometimes associated with CO(2) digital subtraction angiography. Controlling DNA translocation speed is critically important for nanopore sequencing as free electrophoretic threading is far too rapid to resolve individual bases. The peak dilation amplitude, peak latency, and mean pupil dilation systematically increase with decreasing speech intelligibility. Variegate porphyria in South Africa, 1688-1996--new developments in an old disease. Analysis of IGS length polymorphism is therefore an efficient tool for investigating genetic relationships between genets and within progenies in natural fungal populations. Changes in G-protein-coupled signaling correlated, but were not directly linked, to increased neuronal synaptic transmission, Caspase 3 activation and apoptosis.

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The role of Kupffer cells in the clearance of malaria sporozoites from the circulation. One patient was excluded due to concurrent illness unrelated to the intervention, so the data from 63 patients were analyzed. Effect of d-tubocurarine, decamethonium and succinyldicholine on the electrically stimulated guinea pig ileum. This knowledge may be beneficial in the prevention and treatment of tumors caused by foreign body implantation. After appropriate control for potential confounders and prenatal exposures, prenatal exposure to cocaine, alcohol, and cigarettes each independently predicted birth weight and length. A new study uses tools from synthetic biology to probe collective motor function. This study also revealed that the NTS2 FLIPR assay designation for a compound, agonist, partial agonist, and so forth, did not correlate with its in vivo activity as observed in the thermal tail-flick acute model of pain.

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Therefore, high-performance solution-processed nanotube transistors with a 15 nm channel length were obtained by combining a top-gate structure and gate insulators made of a high-dielectric-constant ZrO(2) film. The Huggins band of ozone is investigated by means of exact dynamics calculations using a new (diabatic) potential energy surface for the (1)B(2) state risperdal consta drug class . Eighteen normal-hearing and 18 mildly hearing-impaired subjects performed the test in a paired comparison (A/B) task. Iron-chelating peptides were isolated using immobilized metal affinity chromatography (IMAC). This article discusses the various factors that may influence the electrocardiogram in pediatric patients taking psychotropic drugs and recommendations for monitoring these patients. Dabigatran resulted in a dose-dependent increase in serum creatinine (Scr) and hematuria in both control and 5/6 nephrectomy rats.

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On the aerosol therapy with pure moronal in Monilia infections of the respiratory tract. Forty-eight subjects, criminal defendants who had histories of substantial animal cruelty, were matched with defendants without this history. Since there is little information about this issue in Iran, the present study was conducted to evaluate prevalence of metabolic syndrome and its components in patients with colorectal cancer. The aim of this systematic review was to evaluate the prevalence of serious bleeding events in patients receiving activated protein C. We report a case of a patient with simultaneous stent thrombosis in two coronary arteries following discontinuation of clopidogrel for an elective noncardiac surgery 3 years after DES placement. However, the placenta and ovaries showed metastases from the maternal pPNET. Thus, HTs are generally administered sequentially, delaying the need for cytotoxic chemotherapy, which often reduces QOL. Our findings suggest that more recent smoking cessation treatment-seeking cohorts in a low prevalence region were characterised by less smoking severity, more severe symptoms of depression and were more likely to be male and from a minority racial/ethnic group. This nanoformulation significantly decreased the atherosclerotic lesion area at the aortic sinus, compared with that in untreated mice. Association between 276G/T adiponectin gene polymorphism and new-onset diabetes after kidney transplantation.

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The ACS/rhBMP-2 systems tested demonstrated small but significant differences in the in vivo retention of rhBMP-2. The genetic selection system, combined with biochemical characterization of active mutant proteins, affords three major benefits. Retrospective analysis was carried out to evaluate the prognostic value of urothelial dysplasia with superficial bladder cancer. The King-Devick (KD) oculomotor test has recently been advocated for sideline diagnosis of concussion. Multifocal motor neuropathy (MMN) is a chronic, immune-mediate, peripheral myelinopathy. Temperature-jumped CD experiments revealed biphasic kinetics for the refolding process of heat-denatured ovalbumin, with the features of increasing and subsequently decreasing amplitude of the rapid and the slow phases, respectively, with the decrease in folding temperature. The most life-threatening aspects of cancer are invasion and metastasis. By January 1998, most Canadian cereal grains (e.g., white flour) were being fortified with folic acid, with a large percentage being fortified by mid-1997. The current study examines the link between the experience of divorce in childhood and several indices of adjustment in adulthood in a large community sample of women.

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Higher total node counts reported by pathologists are associated with improved survival. Effects of six diterpenes on macrophage eicosanoid biosynthesis. In this review, we examine how steroid hormones that are produced by the gonads and adrenal glands vary across the lifespan in a range of mammalian and bird species, and we summarise the evidence that steroid hormone exposure influences behavioural and brain development during early stages of life and during adolescence in these two taxonomic groups. The intranuclear organization of normal, hemizygous and excision-deficient rRNA genes during developmental amplification in Tetrahymena thermophila. Role of mitochondrial GrpE and phosphate in the ATPase cycle of matrix Hsp70. Although gastric mucosa also produces amylin, studies on its cellular site of production have yielded highly divergent results, localizing this peptide to either gastrin, serotonin, or somatostatin cells or to combinations thereof. Finally, increased expressions of active uPA, MMP-9, pro MMP-2 and active MMP-2 were also observed in cells transfected with pcDNA3-AE.

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The role of environmental health officers in primary health care. Comparison of the location of var genes in a field isolate showed that it does not have any detectable subtelomeric deletions as all chromosomes contain var genes and rep20 sequences. We have conducted a Phase I trial in which patients with metastatic breast and renal cancer were treated with a vaccine prepared by fusing autologous tumor and DCs. A kinetic analysis of the data, based on Avrami-type kinetics, indicates that the decomposition is independent of the initial A-site composition, and the obtained reaction order supports the conclusion that the hexagonal phase grows at the grain boundaries in dense ceramic samples. The epithelium was removed in both eyes of 5 Dutch belted rabbits by 1 of 5 techniques: blunt mechanical debridement (with a blunt spatula), sharp mechanical debridement (with a sharp scalpel blade), application of topical alcohol, and transepithelial removal with the excimer laser and with the rotary epithelial scrubber. Urinary incontinence is more common in persons with PWS than in typically developing children, adolescents and adults. It is after all the backbone of the vaccination programmes and though often consigned to the technicians, the vaccine cold chain requires constant training of the clinical staff that administers vaccines. falciparum depends heavily on sialic acid present on glycophorins to invade erythrocytes. The ataxic symptoms appeared after an afebrile period of 2-7 days.

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Psychomotor dysfunction in depression is related to alterations in the 24-h pattern of motor activity. Potentiation of NO-dependent activation of soluble guanylyl cyclase by 5-nitroisatin and antiviral preparatation arbidol. Consequently, in our practice, aspirin intake is interrupted on hospitalisation, one day before surgery. Endothelin-converting enzyme-1 (ECE-1) expression cefaclor oral suspension uses in hindi and endothelin-1 peptide level was upregulated in myocardium of heart failure patients without ACE inhibition. Relative importance of local and collective effects in the distortivity of one-dimensional chains. The small round cell tumours of the bone marrow, the spleen and the lymph node was excluded from our study. Behavioral changes, including psychotomimetic effects, were assessed using the Brief Psychiatric Rating Scale (BPRS).

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We document substantial population-level variability among these organisms driven by segmental gain and loss. bystolic generic options We have also shown that beta-carboline-3-carboxylic acid is released from both scorpion exuvia (the shed cuticle) and human cataracts upon hydrolysis, suggesting that the protein-bound beta-carboline and free beta-carboline have common chemical origins. Comparisons indicated that the 20 states which adopted English as their official language since 1984 had lower percentages of high school graduates and higher rates of motor vehicle fatalities among their residents than did those states that did not enact such laws. The following expenses were considered: Harmonic Scalpel impulse generator and disposable shears, operating room cost per hour, and endoclip applier. Absence of p53 functional abnormalities excluded relationships between CCSK and CMN as in AWT, supporting the association of cellular CMN with congenital fibrosarcomas as more recently proposed. In the study, 30 cases of fresh peripheral nerve injury in the upper extremities were recruited. The purpose of the current investigation was (1) to test whether the 3-factor structure of the 20-item Toronto Alexithymia Scale (TAS-20) corresponding to the theoretical conceptualization of the alexithymia construct could be recovered in a Greek translation of the scale (the TAS-20-G), (2) to assess if a 3-factor structure provides a better fit to the TAS-20-G compared with the recently proposed alternative factor structures, and (3) to evaluate the internal reliability of the TAS-20-G.

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